83 Penicillium islandicum Soppの生産するDNA合成阻害物質の構造

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Two typical mycotoxins, luteoskyrin and cyclochlorotine have so far been isolated from the culture broth of Penicillium islandicum Sopp known as an infectant of yellowed rice. In this report, we describe the isolation and the structural elucidation of the new metabolites(named islandic acid-I and -II) which are the inhibitors of DNA synthesis on the transfection assay using Bacillus phage M_2, Bacillus subtilus 222 strain. The ^1H-nmr decoupling studies and the ^<13>C-nmr spectral analysis of islandic acid-I methyl ester[m/e 364, C_<18>H_<20>O_8] revealed the presence of the partial structures [A], [B], [C], [D], [E] and [F]. The order of the arrangement of the partial structures were determined by the application of long range selective proton decoupling and the structures of islandic acid-I and -II were confirmed as 1 and 2.
天然有機化合物討論会の論文
1980-09-10