28 キラル重水素標識N-結合型糖鎖モデルの立体配座解析(口頭発表の部)

概要

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Model N-linked oligosaccharides chirally deuterated at C-6 were synthesized and ^1H-NMR of the model saccharides were measured in order to clarify the conformational preference about (1-6) glycosidic linkages in aqueous solution. The signals of H-6S and H-6R were discriminated unequivocally in these oligosaccharides and the rotamer populations about C-5-C-6 single bonds (ω angle) were calculated from the values of J_<5,6S> and J_<5,6R>. The preferred conformations of φ and ψ angles were estimated on the bases of the differential relaxation rates and the NOE data. In these branched oligosaccharides, the gg rotamer was preferred and the tg rotamer was negligible. The rotamer populations of ω angle of "bisectGlcNAc" model was different from other branched oligosaccharides. These works provides the experimental evidences to the previous estimation of the conformation about (1-6)glycosidic linkage.
天然有機化合物討論会の論文
1987-07-25