41 キラル重水素化法、NMR並びに理論計算(HSEA)法による糖鎖(1-6)結合軸の安定配座解析(口頭発表の部)

概要

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Three dimensional structures of oligosaccharide chains largely depend on the conformational properties of the (1-6)-linkage at the branching points. In a series of our conformational studies on mono- and di-saccharides, we have applied our method of chiral deuteration at the C-6 position of D-hexose and D-pentoses to differentiate the H-6R and H-6S signals in the 1H-NMR spectroscopies. In this study, the method was successfully applied for the conformational anlyses on four branching tri-saccharides (I-IV) as follows; The Chiral deuteration at the the (1-6)-linkage moiety of I-IV, NMR (chemical shifts, coupling constants, NOE) and HSEA calculation enabled us to determine the conformational properties of the (1-6)-linkage moitey and compare the possible interactions between the 0-4 and the 0-6 residues among I-IV to show that the β-D-G1c residue at 0-4 in III and IV stabilizes the gg-conformation.
天然有機化合物討論会の論文
1988-09-26