REGIO- AND STEREOSELECTIVE HYDROXYLATION OF GRINDELIC ACID AND ITS 3α-HYDROXY DERIVATIVE
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概要
- 論文の詳細を見る
A hydrocyl group was selectively introduced at the C-17 or C-6 position of grindelic acid (1a) and 3α-hydroxygrindelic acid (1b) via the 17- or 7β-bromo derivatives (6a, b or 9a, b) given respectively by bromination with Br_2 or NBA. The 7β-hydroxy derivatives (17a, b) were obtained via the 8β-methyl-7-one derivatives (14a, b) by reduction with NaBH_4. The 7α-hydroxy derivatives (18a, b) were obtained selectively from the 8,9-en-7-one derivatives (15a, b) which contain a cleaved structure at the C-9 position.
- 公益社団法人日本薬学会の論文
- 1991-08-25
著者
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清水 猛
理研
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平沼 佐代子
The Institute of Physical and Chemical Research (RIKEN)
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吉岡 宏輔
The Institute of Physical and Chemical Research (RIKEN)
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平沼 佐代子
RIKEN(Institute of Physical and Chemical Research)
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清水 猛
RIKEN(Institute of Physical and Chemical Research)
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吉岡 宏輔
RIKEN(Institute of Physical and Chemical Research)
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