CHEMICAL MODIFICATION OF APHIDICOLIN AND THE INHIBITORY EFFECTS OF ITS DERIVATIVES ON DNA POLYMERASE α IN VITRO(Communications to the Editor)
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概要
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Various derivatives of aphidicolin (1) were prepared and their inhibitory effects on purified DNA polyrmerase α in vitro were assayed. Among these derivatives, the new 3α-, 17, 18-trihydroxyaphidicol-15-ene (24) was as inhibitory as the known 3-deoxy- and 3-oxoaphidicolins, (20) and (14). All the other derivatives with modification of any of the hydroxyl groups of 1 had no effect on the enzyme in vitro. The structure-activity relationships are discussed concerning functionalization on the aphidicolane ring.
- 公益社団法人日本薬学会の論文
- 1987-04-25
著者
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中根 英雄
Laboratory Of Viral Oncology Aichi Cancer Center Research Institute
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小野 克彦
Laboratory Of Viral Oncology Aichi Cancer Center Research Institute
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清水 猛
理研
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平沼 佐代子
The Institute of Physical and Chemical Research (RIKEN)
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吉岡 宏輔
The Institute of Physical and Chemical Research (RIKEN)
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平沼 佐代子
Institute of Physical and Chemical Research
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清水 猛
Institute of Physical and Chemical Research
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吉岡 宏輔
Institute of Physical and Chemical Research
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小野 克彦
Aichl Cancer Center Research Institute
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中根 英雄
Aichl Cancer Center Research Institute
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高橋 泰常
Aichl Cancer Center Research Institute
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