Differential Inhibitory Effects of Various Herb Extracts on the Activities of Reverse Transcriptase and Various Deoxyribonucleic Acid (DNA) Polymerases
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概要
- 論文の詳細を見る
Forty preparations of the extracts from 28 kinds of Asian herbs were tested for ability to inhibit the activities of murine retroviral reverse transcriptase and human deoxyribonucleic acid (DNA) polymerases. Among the 40 extracts, 35 inhibited reverse transcriptase activity and 29 inhibited DNA polymerase α activity. The inhibitory potencies of these extracts were expressed as the 50% inhibition concentrations (IC_<50>), at which the enzyme activities were inhibited by 50%. Very strong inhibitions were observed with the extracts from Millettia pachycarpa (Leguminosae) and Mallotus apelta (Euphorbiaceae) as shown by their low IC_<50> values for reverse transcriptase (0.4-0.5 μg/ml) and DNA polymerase α(0.9-1.4 μg/ml). Enzyme kinetic analysis revealed that the mode of inhibition of reverse transcriptase by these two extracts was competitive with respect to the template・primer [poly(rA)・oligo(dT)] and noncompetitive with respect to deoxythymidine triphosphate (dTTP) substrate. Besides reverse transcriptase and DNA polymerase α, DNA polymerase I and ribonucleic acid (RNA) polymerase from E. coli were inhibited by these two extracts. These results indicate that the herb extracts contain as yet unidentified substance(s) which inhibit the activities of reverse transcriptase and cellular DNA polymerases.
- 社団法人日本薬学会の論文
- 1989-07-25
著者
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坂井 至通
岐阜県保健環境研究所
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水野 瑞夫
岐阜薬科大学
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坂井 至通
Gifu Prefectural Institute of Public Health
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小瀬 洋喜
Gifu Women's Junior College
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水野 瑞夫
Gifu Pharmaceutical University
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中根 英雄
Laboratory Of Viral Oncology Aichi Cancer Center Research Institute
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小瀬 洋喜
(財)岐阜県公衆衛生検査センター
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小野 克彦
Laboratory Of Viral Oncology Aichi Cancer Center Research Institute
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小瀬 洋喜
名古屋市衛生研究所
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孟 正木
China Pharmaceutical University
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