BIOSYNTHESIS OF CHALCOMORACIN AND KUWANON J, THE DIELS-ALDER TYPE ADDUCTS, IN MORUS ALBA L. CELL CULTURES

スポンサーリンク

概要

• 論文の詳細を見る

• Experiments with [1-^<13>C]-, [2-^<13>C]- and [1,2-^<13>C_2]-acetates administered to Morus alba cell cultures revealed that both optically active Diels-Alder type adducts chalcomoracin (1) and kuwanon J (2) are formed through the condensation of two molecules of cinnamoylpolyketide-derived skeletons. The 2-arylbenzofuran skeleton of 1 is formed by a novel type cyclization of the cinnamoylpolyketide, followed by decarboxylation. The ^<13>C-labeling of [2-^<13>C] acetate was incorporated into the starter acetate carbons in the biosynthesis of the prenyl moieties of chalcomoracin (1), while that of [1-^<13>C] acetate was not incorporated into the prenyl moieties of 1.

• 社団法人日本薬学会の論文
• 1989-02-25

著者

• 上田 伸一

  Faculty Of Pharmaceutical Sciences Kyoto University

• 上田 伸一

  京大・薬

• 羽野 芳生

  Faculty of Pharmaceutical Sciences, Toho University

• 野村 太郎

  Faculty of Pharmaceutical Sciences, Toho University

• 野村 太郎

  Faculty Of Pharmaceutical Sciences Toho University

• 野村 太郎

  東邦大 薬

• 羽野 芳生

  東邦大薬

関連論文

• Studies on Monoterpene Glucosides and Related Natural Products. LV. Iridane Skeleton Formation from Acyclic Monoterpenes in the Biosynthesis of Iridoid Glucosides in Gardenia jasminoides f. grandiflora Cell Suspension Cultures
• MECHANISM OF IRIDANE SKELETON FORMATION IN THE BIOSYNTHESIS OF IRIDOID GLUOOSIDES IN GARDENIA JASMINOIDES CELL CULTURES
• 29 Streptocarpus dunnii細胞培養におけるキノン類の生合成
• STRUCTURES OF UNUSUALLY PRENYLATED NAPHTHOQUINONES OF STREPTOCARPUS DUNNII AND ITS CELL CULTURES
• 49 イリドイド配糖体の生合成におけるイリダン骨格形成機構について
• 45 プレニルナフトキノン類縁体および関連アントラキノン類の生合成研究
• Studies on Monoterpene Glucosides and Related Natural Products. XXXVII. Biosynthesis of the Iridoid Glucosides in Lamium amplexicaule, Deutzia crenata and Galium spurium var. echinospermon
• 47 クチナシカルス培養細胞によるイリドイド配糖体の生合成研究
• 15 キササゲ(Catalpa ovata)培養組織におけるprenylnaphthoquinone類縁体の産生と生合成
• Uber die Chinone und verwandte Stoffe in hoheren Pflanzen. IV. Zur Biosynthese von Catalpalacton und Catalponol im Holz der Catalpa ovata
• 2 GeraniolからIridoid配糖体への閉環機構
• 30 高等植物におけるプレニルナフトキノン類の生合成研究
• Studies on Monoterpene Glucosides and Related Natural Products. XXIII. Biosynthesis of the Secoiridoid Glucosides, Gentiopicroside, Morroniside, Oleuropein, and Jasminin
• 49 キササゲのcatalpalactoneおよび類縁物貭の生合成研究
• Studies on Monoterpene Glucosides and Related Natural Products. XVIII. Formation Sequences of Iridoid Glucosides in highly Oxidized Levels
• Studies on Monoterpene Glucosides and Related Natural Products. XVII. The Intermediacy of 7-Desoxyloganic Acid and Loganin in the Biosynthesis of Several Iridoid Glucosides
• アケボノソウSwertia bimaculataのXanthone類について
• Studies on Monoterpene Glucosides and Related Natural Products. XIII. Incorporation of [10-^C]-Sweroside into Gentiopicroside and the Alkaloids in Vinca and Cincona Plants
• Studies on Monoterpene Glucosides. XII. Biosynthesis of Gentianaceous Secoiridoid Glucosides
• 42 イリドイド配糖体の酸化順序とloganinのセコイリドイド配糖体への環開裂の機構
• 78(P59) グアニジル基を有するデプシペプタイド抗真菌抗生物質(LI-Fs)の構造(ポスター発表の部)
• P-67 クワカルスにおける二つのp-クマロイルCoA生合成経路(ポスター発表の部)
• P-58 クワカルスのイソプレン生合成に対するHMG-CoA還元酵素阻害剤の効果と同カルスの新規配糖体の生合成について(ポスター発表の部)
• 45 クワカルスのプレニルカルコン生成過程における水酸化の時期について(口頭発表の部)
• 102 クワカルスにおけるDiels-Alder型付加化合物の一次代謝物からの生合成過程(ポスター発表の部)
• 1 クワカルスにおけるβ-シトステロールとDiels-Alder型付加化合物のイソプレニル単位の生合成(口頭発表の部)
• 37 光学活性Diels-Alder型付加化合物の生合成研究(口頭発表の部)
• BIOSYNTHESIS OF CHALCOMORACIN AND KUWANON J, THE DIELS-ALDER TYPE ADDUCTS, IN MORUS ALBA L. CELL CULTURES
• 20 クワカルスを用いたDiels-Alder型付加化合物の生合成研究(ポスター発表の部)
• FOUR NEW NATURAL DIELS-ALDER TYPE ADDUCTS, MULBERROFURAN E, KUWANON Q, R, AND V FROM CALLUS CULTURE OF MORUS ALBA L.
• Studies on the Constituents of Asclepiadaceae Plants. XLV. On the Components of Metaplexis japonica MAKINO. VI. The Structures of 7-Oxygenated-Pregnane Derivatives
• Components of Metaplexis japonica MAKINO
• Studies on the Constituents of Asclepiadaceae Plants. XVIII. Components of Cynanchum paniculatum KITAGAWA
• Studies on the Constituents of Asclepiadaceae Plants. XX. Epimerization at C-17 and Optical Rotatory Dispersion Study of C/D cis Pregnan-20-one Derivatives. 2
• Studies on the Constituents of Asclepiadaceae Plants. XIX. Components of Metaplexis japonica MAKINO. IV.
• Constituents of Asclepiadaceae Plants. XVII. Components of Cynanchum wilfordi HEMSLEY
• Studies on the Constituents of Asclepiadaceae Plants. XVI. On the Components of Metaplexis japonica MAKINO. III. The Structure of benzoylramanone.
• Studies on the Constituents of Asclepiadaceae Plants. XV. On the Components of Metaplexis japonica MAKINO. II
• Studies on the Constituents of Asclepiadaceae Plants. XIV. Structure of Tomentogenin
• On the Structure of Pergularin
• 15.C/D-cis-pregnane-20-one型化合物の側鎖の異性化及び旋光分散について
• On the Structure of Tomentogenin
• On the Structure of Metaplexigenin and Benzoylramanone
• Studies on the Constituents of Asclepiadaceae Plants. XI. Separation of New Aglycones from Cynanchum caudatum MAXIM.
• Studies on the Constituents of Asclepiadaceae Plants. IX. On the Components of Cynanchum caudatum MAX.
• Studies on the Constituents of Asclepiadaceae Plants. VIII. On the Components of Metaplexis japonica MAKINO. 1.
• Studies on the Constituents of Asclepiadaceae Plants. VII. Paper Chromatographic Separation of Steroidal Aglycones in Asclepiadaceae Plants.
• Studies on the Constituents of Asclepiadaceae Plants. VI. On the Components of Marsdenia tomentosa DECNE.
• 28.CynanchogeninおよびPenupogeninの構造
• Components of Broussonetia kazinoki SIEB. I. : Structures of Two New Isoprenylated Flavans and Five New Isoprenylated 1,3-Diphenylpropane Derivatives
• 80(PB2-10) Streptomyces hygroscopicus var. crystallogenesより得られる抗菌性物質(ポスター発表の部)
• プレニールフラボノイドの化学と生合成
• 天然産Diels-Alder型付加化合物の化学
• Structures of Three New Diterpenoids, Fritillebic Acid and Fritillebins A and B, from Bulbs of Fritillaria ebeiensis G. D. Yu et G. Q. JI
• 70(P49) 中国産桑白皮より得られるフェノール性成分sanggenon類の構造訂正について(ポスター発表の部)
• 50(P-17) クワ(Morus alba L.)カルスにおけるDiels-Alder型付加反応に関与する酵素について(ポスター発表の部)
• 92(P32) 中国産駱駝蒿(Peganum nigellastrum)より得られる新規アルカロイド成分の構造(ポスター発表の部)
• P-10 Rec-assay による薬用植物の生物活性物質検索
• 29G-07 カンゾウおよび桑根皮より得られるプレニルフェノールのエストロゲン様活性
• イソプレノイドの新しい生合成経路
• 86(P15) 宮古島栽培ウコンより得た2種の新規ゲルマクラン型セスキテルペンの立体化学とCDスペクトルについて(ポスター発表の部)
• 71 イソプレノイド側鎖を有するフラボノイドのNMRおよびMassスペクトル(ポスター発表の部)
• 27 天然有機化合物のFAB-MSで遭遇した二、三の基礎的問題点(ポスター発表の部)
• FABMSにおける低極性有機化合物のための新しいマトリックス系の効果
• 1 桑根皮より得られるDiels-Alder型付加化合物の絶対構造
• Structures of Three New 2-Arylbenzofuran Derivatives from the Chinese Crude Drug "Sang-Bai-Pi" (Morus Root Bark)
• Studies on the Dibenzo-p-dioxin (Diphenylene Dioxide) Derivatives. XXXIX. Electron Spin Resonance Absorption Spectra of Dibenzo-p-dioxin Derivatives in Antimony Pentachloride.
• Studies on the Dibenzo-p-dioxin (Diphenylene Dioxide) Derivatives. XXXVIII. The Color Reaction of Dibenzo-p-dioxin Derivatives in Concentrated Sulfuric Acid with Oxidizing Agents. The Detection by Electron Spin Resonance Spectra.
• 33 イリドイド配糖体セコイリドイド配糖体ならびに関連アルカロイドの生合成
• Effects of Flavonoids and Related Compounds from Mulberry Tree on Arachidonate Metabolism in Rat Platelet Homogenates
• Constituents of Morus alba L. Cell Cultures. (1). : Structures of Four New Natural Diels-Alder Type Adducts, Kuwanons J, Q, R, and V
• KUWANON J, A NEW DIELS-ALDER ADDUCT AND CHALCOMORACIN FROM CALLUS CULTURE OF MORUS ALBA L.
• Inhibition of Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase by Phenolic Constituents of Mulberry Tree
• Uber die Monoterpenglucoside. X. Secoiridoid-Glucoside aus Swertia japonica. Isolierung von funf Secoiridoid-Glucosiden sowie die Strukturaufklarung des Swerosids, des Swertiamarins und des Gentiopicrosids
• ポリアミドクロマトグラフィーの研究(第2報) : 数種のフェノール性物質分離へのポリアミドカラムクロマトグラフィーの応用
• せんぶりSwertia japonica MAKINOより得られる人工塩基について
• モノテルペン配糖体の研究(第4報) : ユズリハDaphniphyllum macropodum MIQ.のモノテルペン配糖体
• Components of Broussonetia papyrifera (L.) VENT. I. Structures of Two New Isoprenylated Flavonols and Two Chalcone Derivatives
• Structures of a Novel 2-Arylbenzofuran Derivative and Two Flavone Derivatives from the Cultivated Mulberry Tree (Morus lhou KOIDZ.)
• Structures of Two Natural Hypotensive Diels-Alder Type Adducts, Mulberrofurans F and G, from the Cultivated Mulberry Tree (Morus lhou KOIDZ.)
• Structures of Three New Natural Diels-Alder Type Adducts, Kuwanons P and X, and Mulberrofuran J, from the Cultivated Mulberry Tree (Morus lhou KOIDZ.)
• STRUCTURE OF MULBERROFURAN I, A NOVEL 2-ARYLBENZOFURAN DERIVATIVE FROM THE CULTIVATED MULBERRY TREE (MORUS BOMBYCIS KOIDZ.)
• 桑の根皮よリ得られるDiels-Alder付加化合物の質量分析
• 20 桑の根皮より得られる新フェノール性化合物の構造
• STRUCTURE OF MULBERROFURAN H, A NOVEL 2-ARYLBENZOFURAN DERIVATIVE FROM THE CULTIVATED MULBERRY TREE (MORUS LHOU (SER.) KOIDZ.)
• チオグリセロールをマトリックスとしたプレニルフラボノイド類のFABマススペクトロメトリー
• Components of Broussonetia kazinoki SIEB. (2). : Structures of Four New Isoprenylated 1,3-Diphenylpropane Derivatives, Kazinols J, L, M, and N
• Components of Broussonetia papyrifera (L.) VENT. III. : Structures of Two New Isoprenylated Flavonols, Brossoflavonols C and D
• 93 桑根皮に存在する色素類および関連化合物について
• Gardenia 属植物培養細胞におけるイリドイド配糖体の生産
• STRUCTURE OF KUWANON P, A NEW DIELS-ALDER TYPE ADDUCT FROM THE ROOT BARK OF THE CULTIVATED MULBERRY TREE (MORUS LHOU (SER.) KOIDZ.)
• Studies on the Constituents of the Cultivated Mulberry Tree. II. Photo-oxidative Cyclization of Morusin
• Studies on the Constituents of the Cultivated Mulberry Tree. I. Three New Prenylflavones from the Root Bark of Morus alba L.
• Photo-oxidative Cyclization of Morusin
• Phenolic Constituents of the Cultivated Mulberry Tree (Morus alba L.)
• Studies on the Constituents of the Cultivated Mulberry Tree. III. Isolation of Four New Flavones, Kuwanon A, B, C and Oxydihydromorusin from the Root Bark of Morus alba L.
• Kuwanon A, B, C and Oxydihydromorusin, Four New Flavones from the Root Bark of the Cultivated Mulberry Tree (Morus alba L.)
• Studies on the Dibenzo-p-dioxin (Diphenylene Dioxide) Derivatives. XL. Electron Spin Resonance Spectra of Dibenzo-p-dioxin-2,7-dicarboxylic Acid and 2,7-Disulfonic Acid.
• Kuwanon G, a New Flavone Derivative from the Root Barks of the Cultivated Mulberry Tree (Morus alba L.)
• 桑白皮の品質に関する研究(1) : 成分組成に基づく桑白皮の基原

もっと見る 閉じる

スポンサーリンク