33 イリドイド配糖体セコイリドイド配糖体ならびに関連アルカロイドの生合成

概要

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(10-^<14>C)-Sweroside (I) was proved to be incorporated into reserpinine (IX) in Vinca major, and quinine (X) in Cinchona succirubra. In an attempt to clarify the biosynthetic routes of several iridoid glucosides, (10-^3H)-bisdesoxydihydrodeacetylasperulosidic acid (XIII) was administrated to several plants containing the glucosides. This labelled compound (XIII) was found to be incorporated into loganin (IV) in Lonicera japonica, verbenalin (XV) in Verbena officinalis, geniposide (XVI) and gardenoside (VIII) in Gardenia jasminoides, asperuloside (VI) in Daphniphyllum macropodum, and aucubin (VII) in Aucuba japonica. (10-^3H)-loganin (IV), (10-^3H)-7-epiloganin (XXVII), (7-^3H)-loganin (IV), and (7-^3H)-7-epiloganin (XXVII) were then fed into Daphniphyllum macropodum, respectively, and the asperuloside (VI) derived from all but the last one (XXVII) was found to be radioactive. (10-^3H)-loganin (IV) was also incorporated into gentiopicroside (III). From these feeding experiments, it was deduced that these iridoid glucosides are biosynthesized along the routes shown in scheme 5.
天然有機化合物討論会の論文
1969-09-01