P-58 クワカルスのイソプレン生合成に対するHMG-CoA還元酵素阻害剤の効果と同カルスの新規配糖体の生合成について(ポスター発表の部)

概要

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Morus alba cell cultures have at least two mevalonate pools, one of which is that for isoprenyl-chalcones and the other is that for sterols. In the administration experiment with [2-^<13>C]acetate in the presence of compactin (3), a potential HMG-CoA reductase inhibitor, to the M. alba cell cultures, [2-^<13>C] acetate was incorporated into the isoprenyl units of the prenylchalcone chalcomoracin (1), while the acetate was not incorporated into the isoprene units of β-sitosterol (2). These results suggest that compactin (3) is a specific inhibitor of sterol biosynthesis. Non-inhibition of compactin (3) against the biosynthesis of the prenyl moieties of 1 could be due to the difference of the reaction compartment. Two new stilbene diglucosides 5 and 6, and a new 2-arylbenzofuran diglucoside 7 were isolated from the M. alba cell cultures along with a known glucoside mulberroside A (4). Compound 5 having a cis-stilbene skeleton is a geometric isomer of 4. Biosynthetic study of 5 on administration of [1,3-^<13>C_2]glycerol and [U-^<13>C_6]-D-glucose revealed that the stilbene skeleton is originated from a cinnamoylpolyketide and that the glucose residue of 5 comes from the intact glucose as well as glucose reconstructed from two triose phosphate metabolites.
天然有機化合物討論会の論文
1994-09-20