<原著>柴胡剤の薬理学的研究(第5報) : サイコサポニンの薬理作用と下垂体 : 副腎系との関連性について

概要

論文の詳細を見る
The effects of adrenolectomy on various pharmacological actions of saikosaponin-d (anti-granulomatous activity, effects on various hepatic enzyme activities and effects on serum levels of cholesterol and triglyceride) were investigated. The anti-granulomatous action of saikosaponin-d (0.3 mg/kg×4 days) was not influenced by adrenolectomy. The rate of the effect lowering hepatic NADPH-cyt. c reductase activity by saikosaponin-d administration was slightly decreased by adrenolectomy but not significant. The actions lowering the serum levels of cholesterol and triglyceride by saikosaponin-d were not observed in the adrenolectomyzed rats. These results show that the anti-granulomatous action is not mediated by adrenal but that the action of saikosaponin-d on lipid metabolism depends on the presence of adrenal.
近畿大学の論文
1983-12-25