Studies on the Absorption, Distribution, Excretion and Metabolism of Ginseng Saponins. IV. Decomposition of Ginsenoside-Rg_1 and -Rb_1 in the Digestive Tract of Rats

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The decomposition of ginsenoside-Rg_1 and ginsenoside-Rb_1 in the rat stomach and large intestine after oral administration was investigated. In the stomach, a part of ginsenoside-Rg_1 was decomposed and six decomposition products were observed on a reversed phase thin-layer chromatogram (TLC). These six compounds were identical with those which were obtained on hydrolysis of ginsenoside-Rg_1 under mild acidic conditions (with 0.1 N HCl, at 37℃). On the other hand, an unidentified deomposition product of ginsenoside-Rb_1 was observed on the TLC of the stomach sample after the oral administration of Rb_1 to rats. The product was different from the decomposition product formed by the hydrolysis of Rb_1 under mild acidic conditions. In the large intestine, Rg_1 was decomposed to ginsenoside-Rh_1 and ginsenoside-F_1 by tetracycline-susceptible bacteria and tetracycline-resistant bacteria, respectively. Ginsenoside-Rb_1 was decomposed to ginsenoside-Rd and two unidentified products by enteric enzyme and tetracyclineresistant bacteria, respectively.
公益社団法人日本薬学会の論文
1983-10-25