4-ヨードチモールの定量法の研究(第5報) : ガスクロマトグラフィー

概要

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A procedure was proposed for the gas-liquid chromatographic determination of 4-iodothymol (I) which is the main component in an anthelminthic preparation, and thymol (II) which was possible to co-exist as impurity. The compounds were extracted from the sample with chloroform and determined with a gas-liquid chromatograph equipped with hydrogen flame ionization detector using n-heptadecane as an internal standard. Conditions for the determination were as follow ; stainless steel column ψ0.3cm×75cm, liquid phase 5% APG-L+1% PEG 6000,supportor Celite 545,carrier gas 30ml/min, programmed temperature 100-190°, 6°/min. Results of the determination of an anthelminthic preparation were shown. The method was also applied for the determination of I in Ascaris lumbricoides of swine treated with a solution (1 : 5000) of I for 5 hours at 37°. The mean recovery of I in the body of ascaride was 92.2% and the incorporated amount of I was about half of the quantity originally applied.
社団法人日本薬学会の論文
1969-01-25