Change of Lipid Peroxide Levels in Mouse Organs after Adriamycin Administration

概要

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The influence of adriamycin (ADR), an anthracycline antitumor antibiotic, on lipid peroxide levels in tissues of male CDF_1 strain mice was investigated by using thiobarbituric acid fluorophotometry, as reported in a previous paper (Tanizawa et al., Chem. Pharm. Bull., 29,2910 (1980)). The body weight of mice decreased markedly after intraperitoneal injection of ADR at a dose of 15 mg/kg. The loss reached 25% of the initial weight on the 6th day. The relative weight of organs such as the heart, liver, kidney and spleen also decreased, with a minimum on the 4th day. In contrasts, the lipid peroxide levels in the heart, liver, kidney and spleen increased rapidly, reaching a peak on the 4th day. The lipid peroxide level in the heart increased by 2.6-fold on the 4th day and the level was maintained, despite subsequent decreases in the liver and kidney. No increase of lipid peroxide levels in the serum and lung was observed after ADR injection in mice. ADR had a greater lipid peroxide-increasing effect in mice than daunomycin at the same dose.
公益社団法人日本薬学会の論文
1983-05-25