Caffeine Enhances Adriamycin Antitumor Activity in Ehrlich Ascites Carcinoma-Bearing Mice

概要

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We examined whether caffeine enhances the antitumor activity of adriamycin (ADR), in terms of prolonging survival in Ehrlich ascites carcinoma (ascites-type)-bearing mice. After administration of ADR at a dose of 0.5 mg/kg/d for 5 d together with caffeine (100 mg/kg/d×5 d), the survival period was increased by 39%. However, caffeine had little effect on this ADR induced-prolongation of survival following administration of ADR at 2.0 mg/kg/d for 4 d. Although a significant increase in ADR concentration in the ascites tumor was seen after administration of ADR at a dose of 0.5 mg/kg, caffeine failed to increase ADR concentration in the ascites tumor after administration of ADR at a dose of 2.0 mg/kg. The effect of caffeine thus appears to be due to its effect on the tumor distribution of ADR.
公益社団法人日本薬学会の論文
1995-01-15