薬用人参サポニンの生体内動態に関する研究

概要

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The pharmacodynamics of ginsenoside-Rg_1 (Rg_1), -Rb_1 (Rb_1) and-Rb_2 (Rb_2) in rats were studied. In these studies, obvious differences were found in their pharmacodynamics. That is, Rg_1 was easily hydrated to the same prosapogenins in both rat stomach and 0.1N HCl solution, but Rb_1 and Rb_2 were little decomposed (metabolised) in rat stomach and a small quantity of their hydroperoxide derivatives were found, but they were easily hydrated to their prosapogenins by 0.1 N HCl. These ginsenosides were decomposed (metabolised) to several prosapogenins by enteric bacteria and enteric enzymes. The modes of their decomposition (metabolism) were respectively different. In particular, the terminal sugar moiety at the C-20 hydroxy group was noted to affect the rates of their decomposition. The amount of Rg_1 and Rb_1 absorbed from the gastrointestinal tract of rat were 1.9% and 0.1% of the dose, respectively. And that of Rb_2 was determined to be 3.7% of the dose by using ^3H-labeled Rb_2. Rg_1 was excreted into the urine and bile in a 2 : 5 ratio. Rb_1 and Rb_2 were mainly excreted into the urine.
公益社団法人日本薬学会の論文
1994-08-25