Stereoselective Synthesis of (E)-11-(2-Chloroethylidene)-6,11-dihydrodibenzo[b, e]thiepin
スポンサーリンク
概要
- 論文の詳細を見る
Three acidic metabolites (5-7) of 6,11-dihydro-11-(3-dimethylaminopropylidene)dibenzo[b, e]thiepin(dothiepin) were prepared. In the synthetic course, a reaction of 6,11-dihydro-11-vinyldibenzo[b, e]thiepin-11-ol (2) with SOCl_2 stereoselectively afforded (E)-11-(2-chloroethylidene)-6,11-dihydrodibenzo[b, e]thiepin (3). The mechanism of this reaction is discussed.
- 公益社団法人日本薬学会の論文
- 1990-04-25
著者
-
林田 三生
Central Research Institute, Kaken Pharmaceutical Co., Ltd.,
-
大石 義孝
Central Research Institute, Kaken Pharmaceutical Co., Ltd.,
-
木村 一彦
Central Research Institute Kaken Pharmaceutical Co. Ltd.
-
大石 義孝
Central Research Institute Kaken Pharmaceutical Co. Ltd.
-
永原 美知子
Central Research Institute, Kaken Pharmaceutical Co., Ltd.,
-
向井 輝夫
Central Research Institute, Kaken Pharmaceutical Co., Ltd.,
-
林田 三生
Central Research Institute Kaken Pharmaceutical Co. Ltd.
-
永原 美知子
Central Research Institute Kaken Pharmaceutical Co. Ltd.
-
向井 輝夫
Central Research Institute Kaken Pharmaceutical Co. Ltd.
関連論文
- Synthesis and Evaluation of (Piperidinomethylene)bis(phosphonic acid) Derivatives as Anti-osteoporosis Agents
- Syntheses of the Optical Isomers of Befunolol・HCl and Their β-Adrenergic Blocking Activities
- イヌおよびヒトの尿中にみられるBefunolol代謝物の主としてマススペクトロメトリーによる同定
- Elimination of 3-Hydroxy-2-nitro-2,3-dihydrobenzo[b]furans to 2-Nitrobenzo[b]furans
- A TYPICAL ELcB PROCESS IN THE ELIMINATION OF 3-HYDROXY-2-NITRO-2,3-DIHYDROBENZO [b] FURANS TO 2-NITROBENZO [b] FURANS
- Reactions of Salicylaldehydes with Bromonitromethane
- Synthesis and Antiallergic Activity of Novel Azaazulene Derivatives
- Preparations of 5-Alkylmethylidene-3-carboxymethylrhodanine Derivatives and Their Aldose Reductase Inhibitory Activity
- Stereoselective Synthesis of (E)-11-(2-Chloroethylidene)-6,11-dihydrodibenzo[b, e]thiepin
- Reaction of Epichlorohydrin with Hydroxybenzo[b]furan
- Preparation of 5-Alkyl-3-carboxymethylrhodanines and Their Aldose Reductase Inhibitory Activity
- Synthesis and Aldose Reductase-Inhibitory Activity of Benzo[b]furan Derivatives Possessing a Carboxymethylsulfamoyl Group