Elimination of 3-Hydroxy-2-nitro-2,3-dihydrobenzo[b]furans to 2-Nitrobenzo[b]furans
スポンサーリンク
概要
- 論文の詳細を見る
β-Elimination of stereoisomeric cis- and trans-3-hydroxy-2-nitro-2,3-dihydrobenzo[b]furans was investigated. The 2,3-dihydrobenso[b]furans were stable under acidic conditions but were easily dehydrated under basic conditions to afford the corresponding 2-nitrobenzo[b]furans. An (ElcB)_R mechanism is proposed on the basis of several lines of evidence obtained from studies on kinetics, ultraviolet spectra, leaving group effect and deuterium isotope effect in the elimination reaction.
- 公益社団法人日本薬学会の論文
- 1988-04-25
著者
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土居 義生
Kyoto Research Institute Kaken Pharmaceutical Co. Ltd.
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大石 義孝
Central Research Institute, Kaken Pharmaceutical Co., Ltd.,
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中西 輝雄
Kyoto Research Laboratories, Kaken Pharmaceutical Co., Ltd.,
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大石 義孝
Kyoto Research Institute, Kaken Pharmaceutical Co., Ltd.,
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中西 輝雄
Kyoto Research Institute Kaken Pharmaceutical Co. Ltd.
-
大石 義孝
Central Research Institute Kaken Pharmaceutical Co. Ltd.
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大石 義孝
Kyoto Research Institute Kaken Pharmaceutical Co. Ltd.
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