Antibacterial Activity and Polarographic Half-Wave Reduction Potential of 2-Nitrobenzo [b] furans
スポンサーリンク
概要
- 論文の詳細を見る
The antibacterial activities of a series of 2-nitrobenzo [b] furan derivatives against St. aureus, B. subtilis, E. coli, Sal. typhimurium, Sal. enteritidis, Sh. flexneri, Pr. vulgaris or Ps. aeruginosa were determined in vitro. Most of the compounds showed considerable activities against the bacteria except Pr. vulgaris and Ps. aeruginosa and one of them was about 30 times as active as nitrofurantoin against St. aureus. Mono- and dimethoxy derivatives (2a, 3a, 4a, 5f) were the most active. The polarographic half-wave potentials (E_<1/2>) of the 2-nitrobenzo [b] furans at pH 7 were in a narrow range of -0.450±0.04 V, whereas the E_<1/2> values of regioisomeric nitrobenzo [b] furans were more negative (-0.560--0.726 V). In the case of 2-nitrobenzo [b] furans, substituent (s) on the benzene ring had little influence on the reduction potential of the 2-nitro group, whereas the antibacterial activity depended markedly on the substituent group (s).
- 公益社団法人日本薬学会の論文
- 1985-07-25
著者
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土居 義生
Kyoto Research Institute Kaken Pharmaceutical Co. Ltd.
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中西 輝雄
Kyoto Research Laboratories, Kaken Pharmaceutical Co., Ltd.,
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大石 義孝
Kyoto Research Institute, Kaken Pharmaceutical Co., Ltd.,
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栗山 澄
Kyoto Research Institute, Kaken Pharmaceutical Co., Ltd.
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中西 輝雄
Kyoto Research Institute Kaken Pharmaceutical Co. Ltd.
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中西 輝雄
科研製薬株式会社京都研究所
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大石 義孝
Kyoto Research Institute Kaken Pharmaceutical Co. Ltd.
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栗山 澄
Kyoto Research Institute Kaken Pharmaceutical Co. Ltd.
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