Reaction of Epichlorohydrin with Hydroxybenzo[b]furan

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概要

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• Epichlorohydrin [^<14>C-1,2] (4) was condensed with 2-acetyl-7-hydroxybenzo[b]furan potassium salt (3) to give two radiochemical regio-isomeric 2-acetyl-7-glycidyloxybenzo[b]furans (5a and 5b). The ratio, 5a/5b, was determined to be 5/7 by using ^<14>C-radioisotopic tracer techniques. The present results showed that the reaction proceeds through two different paths in which the phenolate (3) attacks at C-1 of 4 to give 5a and at C-3 to give 5b, the latter path being more favorable than the former.

• 公益社団法人日本薬学会の論文
• 1983-10-25

著者

• 大石 義孝

  Central Research Institute, Kaken Pharmaceutical Co., Ltd.,

• 中西 輝雄

  Kyoto Research Institute Kaken Pharmaceutical Co. Ltd.

• 大石 義孝

  Central Research Institute Kaken Pharmaceutical Co. Ltd.

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• Elimination of 3-Hydroxy-2-nitro-2,3-dihydrobenzo[b]furans to 2-Nitrobenzo[b]furans
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• A TYPICAL ELcB PROCESS IN THE ELIMINATION OF 3-HYDROXY-2-NITRO-2,3-DIHYDROBENZO [b] FURANS TO 2-NITROBENZO [b] FURANS
• Reactions of Salicylaldehydes with Bromonitromethane
• Preparations of 5-Alkylmethylidene-3-carboxymethylrhodanine Derivatives and Their Aldose Reductase Inhibitory Activity
• Stereoselective Synthesis of (E)-11-(2-Chloroethylidene)-6,11-dihydrodibenzo[b, e]thiepin
• Reaction of Epichlorohydrin with Hydroxybenzo[b]furan
• ベンゾフラン誘導体の薄層クロマトグラフィー
• Preparation of 5-Alkyl-3-carboxymethylrhodanines and Their Aldose Reductase Inhibitory Activity
• Synthesis and Aldose Reductase-Inhibitory Activity of Benzo[b]furan Derivatives Possessing a Carboxymethylsulfamoyl Group

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