Synthesis and Aldose Reductase-Inhibitory Activity of Benzo[b]furan Derivatives Possessing a Carboxymethylsulfamoyl Group

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概要

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• Various benzo[b]futran derivatives with a carboxymethylsulfamoyl group were prepared and evaluated for aldose reductase-inhibitory potency. Most of the compounds displayed significant inhibitory activities (IC_<50>, 10^<-8>-10^<-7>M). Among the test compounds, the compounds having a carboxymethylsulfamoyl group at the 3- or 4-position exhibited the greatest inhibitory potency. Structure-activity trends of the tested compounds are discussed.

• 公益社団法人日本薬学会の論文
• 1989-09-25

著者

• 大石 義孝

  Central Research Institute, Kaken Pharmaceutical Co., Ltd.,

• 大石 義孝

  Central Research Institute Kaken Pharmaceutical Co. Ltd.

• 矢嶋 基之

  Central Research Institute Kaken Pharmaceutical Co. Ltd.

• 永原 美知子

  Central Research Institute, Kaken Pharmaceutical Co., Ltd.,

• 向井 輝夫

  Central Research Institute, Kaken Pharmaceutical Co., Ltd.,

• 梶川 憲男

  Central Research Institute, Kaken Pharmaceutical Co., Ltd.,

• 梶川 憲男

  Central Research Institute Kaken Pharmaceutical Co. Ltd.

• 永原 美知子

  Central Research Institute Kaken Pharmaceutical Co. Ltd.

• 向井 輝夫

  Central Research Institute Kaken Pharmaceutical Co. Ltd.

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• Synthesis and Aldose Reductase-Inhibitory Activity of Benzo[b]furan Derivatives Possessing a Carboxymethylsulfamoyl Group

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