Effects of Food on Bioavailability of Two Indomethacin Capsules Containing Different Sizes of Particles

概要

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Two different indomethacin capsules, a commercial one containing fine drug particles and an experimental capsule containing 125-177μm particles, were employed in this study. The commercial preparation showed faster in vitro dissolution than the experimental one. When administered to humans having normal acidity of the gastric juices, the commercial capsule exhibited higher C_<max> and smaller T_<max> and mean residence time (MRT) than the experimental one both in fasting and nonfasting states, although the two capsules were equivalent in area under the serum concentration-time curve (AUC). The ingestion of a breakfast delayed the gastrointestinal absorption from both preparations, which resulted in larger T_<max>'s and MRT's and smaller C_<max>'s in the nonfasting state. Food, however, did not have any significant effect on the AUC's of the preparations.
社団法人日本薬学会の論文
1990-05-25