Stability of Sulpyrine. III. Copper (II) Ion Catalyzed Oxidation by Molecular Oxygen

概要

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The kinetics of the copper (II) ion catalyzed oxidation of sulpyrine by molecular oxygen was investigated. Sulpyrine was hydrolyzed to 4-methylaminoantipyrine (MAA) and then MAA was oxidized to antipyrinyl-4-peroxide (AP) via 4-aminoantipyrine (AA), and hydroxymethanesulfonate formed in the hydrolysis is not effective on the rate of the oxidation of MAA. Below pH 4 the oxidation of MAA to AP was the rate-determining step. On the other hand above pH 5 the hydrolysis of sulpyrine to MAA was the rate-determining step. The rate constants of the oxidative reactions of MAA to AA, and of AA to AP could not be determined because of the difficulties of determining the reaction orders. The complexation of MAA and AA with copper (II) ion and molecular oxygen was suggested from the observation that the both reactions were of first order with respect to copper (II) ion and of 0.5 order with respect to molecular oxygen.
社団法人日本薬学会の論文
1978-09-25