ガスクロマトグラフィーによる製剤の定量分析(第1報) : 製剤中のアセトアミノフェンおよびその他の配合成分について

概要

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Acetaminophen (AA) and other components in antipyretic preparations were determined by gas chromatography. The stationary phase used was 1% diethylenglycol succinate polyester coated on acid-washed and silanized Chromosorb W (60-80 mesh), and the determination was carried out under the conditions given in Fig.4. AA was quantitatively converted to N, O-diacetyl-p-aminophenol in pyridine-acetic anhydride (4+1) at room temperature, but containing guaiacol glyceryl ether acetylation was carried out by warming at 60° for 20 min. Other components, such as ethoxybenzamide and caffeine, were not affected. Since it was difficult to get a good separation of salicylamide from its acetate as shown in Fig.4-C, salicylamide was not determined. Determination was made successfully by the internal standard method using N, O-diisobutyryl-p-aminophenol. Standard deviation was within 0.46% for AA.
公益社団法人日本薬学会の論文
1968-07-25