Bioavailability of Sugar-Coated Tablets of Thiamine Disulfide in Humans. I. : Effect of Gastric Acidity and in Vivo-in Vitro Correlation
スポンサーリンク
概要
- 論文の詳細を見る
The dissolution of sugar-coated tablets of thiamine disulfide largely depended on the lag time, which was greatly affected by the pH of the medium, and was accelerated by mechanical destructive force. The disintegration time-pH profiles were very similar to the dissolution rate-pH profiles determined by using a disintegration test device. Markedly slow dissolution and disintegration of one of the tablets at pH 7.2 was attributed to the dissolving characteristics of polyvinylacetal-diethylaminoacetate (AEA^<[○!R]>) applied to the tablet as a coating film, and the slow dissolution of another tablet at pH 3-5 was attributed to the use of 2-methyl-5-vinylpyridine-methylacrylate-methacrylic acid copolymer (MPM^<[○!R]>). Six products were tested for bioavailiability. Statistically significant differences were found in bioavailability among the products. Human gastric acidity greatly affected the bioavailability of the tablet that disintegrated poorly at pH 7.2,and the bioavailiability was significantly lower in subjects with low gastric acidity than in those with high gastric acidity. The in vivo parameters of high and low acidity subjects correlated well with the in vitro parameters determined at pH 1.2-5 and pH 5-7.2,respectively.
- 社団法人日本薬学会の論文
- 1986-01-25
著者
-
青柳 伸男
National Institute of Hygienic Sciences
-
緒方 宏泰
National Institute of Hygienic Sciences
-
鹿庭 なほ子
National Institute of Hygienic Sciences
-
江島 昭
National Institute of Hygienic Sciences
-
緒方 宏泰
Department Of Biopharmaceutics Meiji College Of Pharmacy
-
鹿庭 なほ子
国立衛生試験所薬品部
-
柴崎 利雄
National Institute Of Hygienic Sciences
-
鯉渕 昌信
National Institute Of Hygienic Sciences
-
青柳 伸男
国立衛生試験所薬品部
-
鮫島 政義
Product Formulation Research Laboratory Tanabe Seiyaku Co. Ltd.
-
鯉淵 昌信
National Institute of Hygienic Sciences
-
溝辺 雅一
Products Formulation Research Laboratory, Tanabe Seiyaku Co., Ltd.,
-
河野 啓一
Products Formulation Research Laboratory, Tanabe Seiyaku Co., Ltd.,
-
河野 啓一
Products Formulation Research Laboratory Tanabe Seiyaku Co. Ltd.
-
河野 啓一
田辺製薬(株)製品研究所
-
溝辺 雅一
Products Formulation Research Laboratory Tanabe Seiyaku Co. Ltd.
-
鹿庭 なほ子
衛試
関連論文
- Chronic Blood Vessel Catheterization in Gottingen Miniature Pigs and Application to a Preliminary Bioavailability Study of Nalidixic Acid
- 16.プロビタミンDの光学反応用光源 : 都市スモッグによる紅斑性紫外線不足への一対策(第16回大会研究発表要旨)
- Application of Synthetic Hydrated Aluminum Silicates as Orally Administered Absorbents of Ammonium Ion
- 新しい医用計測法
- Bioavailability of Pyridoxal Phosphate from Enteric-Coated Tablets. I. Apparent Critical Dissolution pH and Bioavailability of Commercial Products in Humans
- Bioavailability of Pyridoxal Phosphate from Enteric-Coated Tablets. III. Correlations between Bioavailability in Humans and Beagle Dogs and between Bioavailability in Humans and in Vitro Dissolution Rates
- Establishing a Comprehensive Questionnaire for Detecting Drug-induced Extrapyramidal Symptoms
- ICHの分析法バリデーションについて
- 第十三改正日本薬局方における分析法バリデーションをめぐって
- Gastric Emptying Rate of Drug Preparations. III. Effects of Size of Enteric Micro-Capsules with Mean Diameters Ranging from 0.1 to 1.1 mm in Man
- Effects of Food on Bioavailability of Two Indomethacin Capsules Containing Different Sizes of Particles
- Relase Rates on Indomethacin from Commercial Witepsol Suppositories and the Bioavailabilities in Rabbits and Pigs
- Bioavailability of Sugar-Coated Tablets of Thiamine Disulfide in Humans. II. : Correlation with Bioavailability in Beagle Dogs
- Bioavailability of Sugar-Coated Tablets of Thiamine Disulfide in Humans. I. : Effect of Gastric Acidity and in Vivo-in Vitro Correlation
- Bioavailability of Pyridoxal Phosphate from Enteric-Coated Tablets. II. Effects of Gastric Acidity of Humans
- 生物学的同等性試験における検出力.主としてヒト試験とビーグル犬試験の比較
- 薬局方について
- Estimation of Polymorphic Transition Degree of Pharmaceutical Raw Materials
- ガスクロマトグラフィーによる製剤の定量分析(第5報)ルビジウムアルカリフレーム検出器を用いた綜合感冒剤中のマレイン酸クロルフェニラミン及び塩酸メチルエフェドリンの微量分析
- ラボラトリーロボットによるアジマリン錠含量均一性試験の自動化の試み(品質管理・工程管理のための分析化学)
- The Kinetics of the Racemization of Oxazepam in Aqueous Solution
- Stability of Pilocarpine Ophthalmic Formulations
- 光学活性移動相を用いた高速液体クロマトグラフィーによる製剤中のD-及びL-ドーパの定量(医薬品の分析)
- Influence of Fatty Acid Composition on the Properties and Polymorphic Transition of Fatty Suppository Bases
- Influence of the Liquid Phase Coexisting in Fatty Suppository Bases on the Polymorphic Transition Rate
- The Influence of Drugs on the Physical Stability of Fatty Suppositories
- Polymorphic Transition Rate of Semisynthetic Fatty Suppository Bases
- Stability of Solid Dosage Forms. II. Hydrolysis of Meclofenoxate Hydrochloride in Commercial Tablets
- Stability of Solid Dosage Forms. I. Hydrolysis of Meclofenoxate Hydrochloride in the Solid State
- The Analgesic Effects of The Decomposition Products of Sulpyrine, N-[2-(5-Hydroxymethyl-2,3,4,5-tetrahydro-2,3,4-trihydroxy) furyl] methyl-N-methylantipyrine and Antipyrinyl-4-peroxide
- Stability of Sulpyrine. V. Oxidation with Molecular Oxygen in the Solid State
- Studies on Dissolution Tests of Solid Dosage Forms. IV. Relation of Absorption Sites of Sulfonamides administered orally in Solid Dosage Form to Their Solubilities and Dissolution Rates
- Stability of Sulpyrine. IV. Reaction with Glucose in Aqueous Solution
- Stability of Sulpyrine. III. Copper (II) Ion Catalyzed Oxidation by Molecular Oxygen
- 固型製剤の溶出試験法に関する研究(第1報)イソニコチン酸ヒドラジド錠のBioavailabilityと溶出速度との相関性
- Fluorescence of Boron Complexes. VI. Fluorometric Determination of Salicylic Acids
- Stability of Sulpyrine. II. Hydrolysis in Acid Solution
- Stability of Sulpyrine. I. Reversible Hydrolysis in Alkaline Solution
- 高速液体クロマトグラフ法による体液中のテオフィリンの定量
- 高速液体クロマトグラフ法による混合製剤の分析(第6報)解熱鎮痛剤配合製剤の高速液体クロマトグラフィーによる定量
- 高速液体クロマトグラフ法による混合製剤の分析(第5報)総合感冒剤中の解熱鎮痛剤および抗ヒスタミン剤の高速液体クロマトグラフィーによる定量
- 含量均一性および重量偏差試験の判定基準についての考察
- Drug Interactions between Theophylline and H_2-Antagonists, Roxatidine Acetate Hydrochloride and Cimetidine : Pharmacokinetic Analysis in Rats in Vivo
- 66.日光および医療用紫外線螢光灯照射による油溶液中のエルゴステロールのビタミンD_2への転換(一般研究発表要旨)
- 7.都市排気ガスによる大気汚染の紫外線, とくに310mμ以下の光の吸収量について(第103回会議研究発表要旨)
- 44.大気汚染による日光中の赤斑光線量とプロビタミンDよりビタミンDへの転換量(日本ビタミン学会第17回大会研究発表要旨)
- 油剤中の0,0-Dimethyl2,2-Dichlorovinyl Phosphateの安定性
- 防疫用製剤中のO, O-Dimethyl2,2-Dichlorovinyl Phosphateの新比色定量法
- Determination of Propranolol and Its Major Metabolite, Naphthoxylactic Acid, in Human Plasma by High Performance Liquid Chromatography
- タンパク質と二糖類の凍結溶液における混合性と凍結乾燥時の安定化作用
- 20.ビタミンB_1誘導体の血球内保持性と血球エステラーゼ(第18回大会研究発表要旨)
- 19.ビタミンB_1誘導体の血球膜透過性(第18回大会研究発表要旨)
- 9.O-アシル型ビタミンB_1の血球移行と膜エステラーゼ(第165回会議研究発表要旨)
- Fluorescence of Boron Complexes. VII. Fluorometric Determination of Salicylamide
- ガスクロマトグラフィーによる製剤の定量分析(第6報)炎光光度検出器及び熱イオン化検出器を用いたクロフィブラートカプセル中のパラクロルフェノールの分析
- ガスクロマトグラフィ-による油剤および乳剤中のダイアジノンの定量
- ガスクロマトグラフィーによる製剤の定量分析(第4報)アスピリンアルミニウム配合剤について
- ガスクロマトグラフィーによる製剤の定量分析(第3報)アスピリン, フェナセチンおよびカフェイン配合剤について
- ガスクロマトグラフィーによる製剤の定量分析(第2報)β-Hydroxybutylic Acid-p-phenetidide, エトキシベンズアミドおよびカフェイン配合剤について
- ガスクロマトグラフィーによる製剤の定量分析(第1報) : 製剤中のアセトアミノフェンおよびその他の配合成分について
- 有機水銀製剤中の水銀の新間接吸光光度定量法
- A Systematic Review of the Clinical Effectiveness of Azathioprine in Patients with Ulcerative Colitis
- Evaluation of Bioavailability of Hypolipidemic Compound LK-903
- 臭素・ピリジン水溶液によるチアミンの比色定量
- Microencapsulation of a Slightly Soluble Drug by Surface Neutralization Method Using an Enteric Polymer
- Studies on Dissolution Mechanism of Drugs from Ethylcellulose Microcapsules(Pharmaceutical)
- Powder-Filled Semisolids : Influence of Powder Addition to Vaseline on the Rheological Properties
- Evaluation of the Rheological Properties of Various Kinds of Carboxyvinylpolymer Gels
- A New Method for Preparation of Enteric-Coated Microcapsules from Aqueous Medium(Pharmaceutical)
- Studies on Microcapsules. IV. : Influence of Properties of Drugs on Microencapsulation and Dissolution Behavior
- Studies on Microcapsules. III. Influence of Molecular Weight of Polyisobutylene in the Microencapsulation of Ascorbic Acid
- Application of Nonlinear Viscoelastic Analysis by the Oscillation Method to Some Pharmaceutical Ointments in the Japanese Pharmacopeia
- Mechanism of the Intestinal Absorption of Drugs from Oil in Water Emulsions. V. Enhanced Absorption of Methyl Orange Adsorbed at Oil/Water Interface in Emulsions
- Mechanism of the Intestinal Absorption of Drugs from Oil in Water Emulsions. IV. Absorption from Emulsions containing the Higher Concentration of Emulsifier
- Mechanism of the Intestinal Absorption of Drugs from Oil in Water Emulsions. III. Absorption and Biotransformation of Methyl Orange
- Mechanism of Intestinal Absorption of Drugs from Oil in Water Emulsions. II. Absorption from Oily Solutions
- Mechanism of Intestinal Absorption of Drugs from Oil in Water Emulsions. I
- Absorption and Excretion of Drugs. XXXVI. Effect of Ca^ on the Absorption of Tetracycline from the Small Intestine. (1)
- 胃液酸度簡易検査用剤の開発の試み
- Biopharmaceutical Studies on the Clinical Inequivalence of Two Carbutamide Tablets
- 期待するもの(医薬品品質試験のあり方)
- 目的指向のシンポジウム(薬学関連シンポジウムを考える)
- 製剤安定化とその評価法シンポジウム
- Studies on Microcapsules. II. Influence of Molecular Weight of Ethylcellulose in the Microencapsulation of Ascorbic Acid
- Studies on Microcapsules. I. Role and Effect of Coacervation-inducing Agents in the Microencapsulation of Ascorbic Acid by a Phase Separation Method
- 〔VI〕解熱鎮痛剤分析へのガスクロマトグラフィーの利用とその問題点について(衛生化学領域におけるガスクロマトグラフィー第4回全国衛研化学技術協議会総会)
- テュニジア国への医薬品品質管理に関する技術協力
- 11.ビタミンA原料および製剤の短期保存試験法の可否(第16回大会研究発表要旨)
- 16.製剤中ビタミンAの異性体の分離にかんする研究(I) : 活性リン酸二石灰を用いるクロマトグラフィー(第15回日本ビタミン学会大会研究発表要旨)
- Studies on Passiflora incarnata Dry Extract. I. Isolation of Maltol and Pharmacological Action of Maltol and Ethyl Maltol
- 13.血球でのO-アシル型ビタミンB_1の挙動(第169回会議研究発表要旨)
- ホウ酸錯塩のけい光(第5報)サリチル酸エステル類のホウ酸錯塩の発けい光性と構造との関連について
- ホウ酸錯塩のけい光(第4報) : サリチルアルデヒドおよびオルトヒドロオキシフェニルケトン類のけい光定量
- Analysis of population pharmacokinetics of disopyramide.
- ホウ酸錯塩のケイ光(第3報) : 食品中のデヒドロ酢酸(DHA)のケイ光定量
- ホウ酸錯塩のケイ光(第2報) : サリチル酸エステル類のケイ光定量
- テヒドロ酢酸およびそのナトリウム塩のホウ酸の無水酢酸溶液によるケイ光定量
- Cyclandelate Capsules の Bioavailability に及ぼす食餌の影響
- タイトル無し
- タイトル無し