高速液体クロマトグラフ法による混合製剤の分析(第5報)総合感冒剤中の解熱鎮痛剤および抗ヒスタミン剤の高速液体クロマトグラフィーによる定量

概要

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A rapid and sensitive high-speed liquid chromatographic assay was developed for acetaminophen, ethoxybenzamide, caffeine, and chlorpheniramine maleate in anti-cold drugs. Acetaminophen, ethoxybenzamide, and caffeine were separated by injection of methanol solution into the column (50 cm×3 mm) packed with Hilachi Gel 3011 (styrene-divinylbenzene copolymer) and eluted with mixture of methanol-28% ammonia water (99 : 1) and detected at 280 nm. Chlorpheniramine maleate was separated by injection of aqueous solurion into the column (50 cm×3 mm) packed with Hitachi Gel 3011,eluted with a mixture of acetonitrile-28% ammonia water (99 : 1), and detected at 225 nm.
社団法人日本薬学会の論文
1979-10-31