混合製剤中のエチル炭酸キニーネの定量

概要

論文の詳細を見る
Quinine ethylcarbonate in pharmaceutical preparations could be determined conveniently by the infrared spectrophotometry. The absorption band at 1755 cm-1 of its carbon disulfide solution was chosen as the key band. The recommended procedure is as follows: A sample which contains about 25 mg of quinine ethylcarbonate is placed in a centrifuge tube, add 25 ml of carbon disulfide and shake the tube for 10 minutes. Centrifuge the contents of the tube, and the residue is treated similarly with 15 ml of the same solvent three times. The whole supernatant liquid is put together, condensed to about 5 ml in vacuo, and diluted to 10 ml with carbon disulfide. Measure the absorbances of this solution (ET) and a standard solution (2.5 mg/ml) (ES) against a solvent blank, and estimate the amount of quinine ethylcarbonate from the ratio of ET to ES.
社団法人日本分析化学会の論文