高速液体クロマトグラフ法による総合感冒剤中の鎮咳剤, 〓痰剤および抗ヒスタミン剤の定量

概要

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Glyceryl guaiacol ether, noscapine, noscapine hydrochloride, chlorpheniramine maleate, diphenhydramine salicylate, diphenhydramine hydrochloride, promethazine methylenedisalicylate, alimemazine tartrate, and isothipendyl hydrochloride in anti-cold preparations were separated successfully, using styrene-divinylbenzene copolymer gel or poly (methyl methacrylate) gel as a stationary phase and a mixture of methanol and concentrated ammonia water as a mobile phase. The separated ingredients were detected by spectrophotometry using an ultraviolet monitor. Methylephedrine hydrochloride was undetected by this method because of its low sensitivity. It must be separated from other ingredients by an ion-exchanger. The separated methylephedrine was oxidized with potassium ferricyanide, chromatographed, and quantitated by substituting methanol for the mixture of methanol and concentrated ammonia water in this procedure.
社団法人日本薬学会の論文
1977-10-31