The Influence of Drugs on the Physical Stability of Fatty Suppositories

概要

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To examine the influence of drugs on the physicochemical stability of semisynthetic fatty suppositories, model suppositories containing various kinds of drugs were prepared with Witepsol H-15 and storage experiments were performed. It was shown that the stability of pharmaceutical properties was largely dependent on the solubility of drugs in the fatty vehicle (S_o). That is, the rate of polymorphic transition of the vehicle measured by X-ray diffraction was accelerated by lipid-soluble drugs but was not much affected by lipid-insoluble drugs. The melting points measured by DTA generally decreased with inrreasing S_o, but they all increased by about 2 or 3℃ during storage. The softening time decreased with increasing S_o. The release properties measured at 37℃ were dependent on the solubility of the drugs in the dissolution fluid (S_w) initially but became dependent on S_o during storage. This phenomenon is discussed on the basis of the transportion mechanism of drugs in the lipid phase.
社団法人日本薬学会の論文
1982-03-25