Effect of Plasticizer on Microencapsulation with Enteric Polymer by Surface Neutralization Method
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概要
- 論文の詳細を見る
Concerning the microencapsulation method based on surface neutralization of enteric polymers, the effect of plasticizer was studied using methacrylic acid-methacrylic acid methyl ester copolymer (Eudragit S). This did not form an effective film on the surface of particles when used with the general surface neutralization method. Microcapsules (MCs) were prepared by suspending crystal aspirin in aqueous Eudragit S solution containing triethyl citrate (TEC) as plasticizer, and the effects of the preparation conditions on the MC properties were investigated.The dissolution of aspirin from the MCs prepared at 60℃ in the artificial gastrointestinal fluid (JP XII 1st fluid) was increasingly suppressed as TEC concentration increased. Most effective suppression of the dissolution required a preparation temperature above 40℃ using 40% TEC, and 60℃ using 20% TEC. With the increase in preparation temperature, the polymer content in MCs increased, but the recovery percent of aspirin and the single nuclear percent of MCs decreased. The polymer content in MCs increased with decreasing crystal size of aspirin, while the membrane thickness and permeability constant were almost the same irrespective of crystal size.The phase separation behaviors of Eudragit S solutions containing TEC were observed at various pHs and temperature and the state of the polymer phase at low pH was recognized to reflect the effect of plasticizer on the microencapsulation.
- 公益社団法人日本薬学会の論文
- 1993-12-15
著者
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小林 征雄
Pharmaceutics Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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小林 征雄
Pharmaceutics Research Laboratory Tanabe Seiyaku Co. Ltd.
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高畑 英夫
Pharmaceutics Research Laboratory Tanabe Seiyaku Co. Ltd.
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