ラボラトリーロボットによるアジマリン錠含量均一性試験の自動化の試み(<特集>品質管理・工程管理のための分析化学)

概要

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A laboratory robot system was applied to content uniformity test and weight variance test of several commercial sugar coated tablets containing 50 mg of ajmaline. The system was composed of robot, balance, stirrer, ultrasonic washer, pipetting module and HPLC system. HPLC was used for determining ajmaline in the tablets and R. S. D. (relative standard deviation) was 0.18%. The system showed good precision ; the R. S. D. of weighing tablets was 0.2% and that of dispensing 0.5 and 1.0ml of water was 0.4 and 0.1%. All samples passed the content uniformity criteria for the Japanese pharmacopoeia, and the variability of the ajmaline contents was from 1.24 to 4.28% of R. S. D. and that of the weights was from 1.30 to 6.05%. In conclusion, the system showed good suitability for these tests.
社団法人日本分析化学会の論文
1988-11-05