Stability of Sulpyrine. II. Hydrolysis in Acid Solution

概要

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Hydrolysis of sulpyrine was studied in acid region. Sulpyrine and the hydrolyzed products were directly determined by NMR spectroscopy. In the pH range between 3 and 7,sulpyrine was found to be in an equilibrium with the hydrolyzed products, mainly 4-methylaminoantipyrine (MAA). A decreases in the rate of hydrolysis and formation of sulpyrine was observed with a decrease in pH value. In the pH range below 3,4-(N-hydroxymethyl-N-methyl) aminoantipyrine (HMA) was detected as a hydrolyzed product in addition to MAA. An equilibrium was attained between supyrine and HMA immediately after sulpyrine was dissolved, and the ratio of the equilibrated amount of HMA to that of sulpyrine was found to increase with a decrease in pH value. Successively the first order hydrolysis of sulpyrine and/or HMA was observed and no equilibrium was attained between sulpyrine and the hydrolyzed products, which indicated that the reverse reaction was negligible.
社団法人日本薬学会の論文
1977-03-25