Effect of the Binding of Water to Excipients as Measured by ^2H-NMR Relaxation Time on Cephalothin Decomposition Rate
スポンサーリンク
概要
- 論文の詳細を見る
^2H-NMR spectra and the relaxation time of deuterium oxide adsorbed on some pharmaceutical excipients were measured using a high resolution NMR spectrometer in order to clarify the effect of the binding of water to some pharmaceutical excipients on drug decomposition. The decomposition rate of cephalothin was determined in the presence of corn starch and MCC as model excipients under various humidity conditions. The decomposition rate increased with the increasing water content of the excipients. The spin-lattice relaxation time increased with increasing water content similarly to the decomposition rate. This suggests that the ^2H-NMR spin-lattice relaxation time can be used as a measure of the water mobility which affects the decomposition rate of drugs in the solid state.
- 社団法人日本薬学会の論文
- 1994-02-15
著者
-
吉岡 澄江
National Institute of Hygienic Sciences
-
阿曽 幸男
国立衛研
-
吉岡 澄江
国立衛研
-
寺尾 允男
National Institute of Hygienic Sciences
-
阿曽 幸男
National Institute of Health Sciences
-
寺尾 允男
国立衛生試験所
-
寺尾 允男
National Institute Of Health Sciences
-
吉岡 澄江
国立薬品食品衛生研究所薬品部室
関連論文
- Amino Acids and Peptides. XXI. : Synthesis of N-Terminal Heptapeptide of Mammalian Metallothionein (MT) and Evaluation of Its Immunoreactivity
- Application of Synthetic Hydrated Aluminum Silicates as Orally Administered Absorbents of Ammonium Ion
- Purification and Characterization of the Product of Chemically Synthesized Human Growth Hormone Gene Expression in Escherichia coli(Biological,Chemical)
- PARTIAL PURIFICATION AND BIOLOGICAL ACTIVITY OF THE PRODUCT OF CHEMICALLY SYNTHESIZED HUMAN GROWTH HORMONE GENE EXPRESSION IN ESCHERICHIA COLI
- 非晶質ジヒドロピリジン系薬物の物理的安定性とαおよびβ緩和時間で表される分子運動性との関係
- タンパク質凍結乾燥製剤の凝集速度に及ぼす局所的分子運動性の影響
- グルコース含有凍結乾燥製剤のガラス転移温度の分子動力学法による推定
- PVPとの固体分散体におけるニフェジピンの結晶化速度の Adam-Gibbs-Vogel 式に基づく解析
- 7. 凍結乾燥製剤の安定性に及ぼす水の影響(セミナー : 生物・食品と水)
- タンパク質凍結乾燥製剤中のデキストランおよびPVPの誘電緩和時間およびNMR緩和時間の比較
- 非晶質ニフェジピンの結晶化速度および構造緩和時間に及ぼすPVPの影響
- 非晶質ニフェジピンおよびフェノバルビタールの結晶化速度とガラス転移温度の昇温速度依存性から算出される緩和時間との関係
- 2. タンパク質凍結乾燥製剤の安定性に及ぼす分子運動性の影響に関する検討(セミナー : 生物資源の保存)
- 化学力顕微鏡による光学異性体の識別
- タンパク質凍結乾燥製剤のガラス転移温度(T_g)とNMR緩和による分子運動性の限界温度(T_)に及ぼす高分子添加剤の影響
- ハイドロゲルの放出特性の指標としてのNMRで測定した拡散係数の有用性
- Water Mobility in Aqueous Solutions of Macromolecular Pharmaceutical Excipients Measured by Oxygen-17 Nuclear Magnetic Resonance
- The Physical Stability of Amorphous Nifedipine Determined by Isothermal Microcalorimetry
- Effect of the Binding of Water to Excipients as Measured by ^2H-NMR Relaxation Time on Cephalothin Decomposition Rate
- Application of Microcalorimetry to Stability Testing of Meclofenoxate Hydrochloride and dl-α-Tocopherol
- NMRでみる水の運動性と医薬品の安定性
- Statistical Evaluation of Accelerated Stability Data Obtained at a Single Temperature. II. : Estimation of Shelf-Life from Remaining Drug Content
- Statistical Evaluation of Accelerated Stability Data Obtained at a Single Temperature. I. : Effect of Experimental Errors in Evaluation of Stability Data Obtained
- Epimerization and Racemization of Some Chiral Drugs in the Presence of Human Serum Albumin
- Amino Acids and Peptides. XXXIII. Synthesis of N-Terminal Epitope Peptides of Mammalian Metallothioneins (MTs)
- An Enzyme Immunoassay System with a Monoclonal Antibody for the Determination of 11-Deoxycortisol(Analytical,Chemical)
- Production and Specificity of a Monoclonal Anti-11-deoxycortisol Antibody
- AN ENZYME IMMUNOASSAY METHOD WITH A MONOCLONAL ANTIBODY FOR THE DETERMINATION OF 11-DEOXYCORTISOL
- PRODUCTION OF A MONOCLONAL ANTI-11-DEOXYCORTISOL ANTIBODY
- Protein Denaturation in Dosage Forms Measured by Differential Scanning Calorimetry
- Epimerization and Racemization of Some Chiral Drugs in the Presence of Cyclodextrin and Liposomes
- FORMULATION-ASSISTED BIODEGRADABLE POLYMER MATRICES
- Epimerization and Hydrolysis of Etoposide Analogues in Aqueous Solution
- Application of Gel Permeation chromatograph-Low Angle Laser Light Scattering System to Kinetic Study on Degradation of Bioerodible Polymers
- The Kinetics of the Racemization of Oxazepam in Aqueous Solution
- Stability of Pilocarpine Ophthalmic Formulations
- Synthetic Hydrated Aluminum Silicates as Oral Adsorbents of Potassium Ion
- 光学活性移動相を用いた高速液体クロマトグラフィーによる製剤中のD-及びL-ドーパの定量(医薬品の分析)
- Stability of Solid Dosage Forms. II. Hydrolysis of Meclofenoxate Hydrochloride in Commercial Tablets
- Stability of Solid Dosage Forms. I. Hydrolysis of Meclofenoxate Hydrochloride in the Solid State
- The Analgesic Effects of The Decomposition Products of Sulpyrine, N-[2-(5-Hydroxymethyl-2,3,4,5-tetrahydro-2,3,4-trihydroxy) furyl] methyl-N-methylantipyrine and Antipyrinyl-4-peroxide
- Stability of Sulpyrine. V. Oxidation with Molecular Oxygen in the Solid State
- Stability of Sulpyrine. IV. Reaction with Glucose in Aqueous Solution
- Stability of Sulpyrine. III. Copper (II) Ion Catalyzed Oxidation by Molecular Oxygen
- Stability of Sulpyrine. II. Hydrolysis in Acid Solution
- Stability of Sulpyrine. I. Reversible Hydrolysis in Alkaline Solution
- Preparation of Monoclonal Antibodies for Immunoblotting Human Growth Hormone Receptor and Growth Hormone-Binding Protein
- 生体膜にあるレセプター
- ジェネリック医薬品の品質保証
- 医薬品の安定性予測と分子運動性
- 1. 高分子ゲルの凍結・融解過程のX線回折-DSC同時測定(平成12年度第46回低温生物工学会研究報告)
- 12. デキストラン水溶液の凍結融解挙動(平成11年度第45回低温生物工学会研究報告)
- DSC等の熱分析による医薬品の安定性評価
- Effect of Mannitol Crystallinity on the Stabilization of Enzymes during Freeze-Drying
- 医薬品承認基準の国際調和
- 日本薬学会と国際化
- The Effect of Staurosporine on Ca^ Signals in Rat Basophilic Leukemia (RBL-2H3) Cells
- 放射性医薬品の最近の話題-2-放射性医薬品基準の解説
- 放射性医薬品の最近の話題-1-放射性医薬品とは
- Effect of Cryoprotectants on the Eutectic Crystallization of NaCl in Frozen Solutions Studied by Differential Scanning Calorimetry (DSC) and Broad-Line Pulsed NMR
- 平成21年度「日本薬局方の試験法に関する研究」研究報告 医薬品添加剤の結晶化度測定法に関する研究
- 熱分析による非晶質医薬品の結晶化の評価
- Chloride Leakage Measurement for the Evaluation of the Plasma-Induced Instability of Liposomal Membrane
- ホウ酸錯塩のけい光(第5報)サリチル酸エステル類のホウ酸錯塩の発けい光性と構造との関連について
- Hoffman 式
- 熱分析による非晶質医薬品の結晶化の評価
- 平成22年度「日本薬局方の試験法等に関する研究」研究報告 医薬品添加剤等の結晶化度測定法に関する研究(その2)