Studies on Synthesis of Coumarin Derivatives. XX. Synthesis and Antibacterial Activity of Derivatives of N-Substituted 3-Coumarincarboxamide

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N-Substituted 6-nitro- and 7-nitro-3-coumarincarboxamides were prepared from these corresponding acids by the Schotten-Baumann reaction. N-(2-Pyridyl)-7-nitro-8-hydroxy-and N-(2-pyridyl)-7-nitro-8-methoxy-3-coumarincarboxamide were also prepared by the fusing of these ethyl esters and 2-aminopyridine. All of N-substituted nitro-3-coumarincarboxamides were derived to the corresponding N-substituted amino-3-coumarincarboxamides by a catalytic reduction and then the acetamido and the nitrofurfurylidene derivatives were finally prepared. Antibacterial tests of these derivatives on tubercle bacilli were carried out and some N-(2-pyridyl) amide and nitrofurfurylidene derivatives showed a strong activity.
公益社団法人日本薬学会の論文
1968-11-25