Synthesis and Antiinflammatory Activity of N^1-(Substituted phenyl) pyridinecarboxamidines

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概要

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• A series of N^1-(substituted phenyl) pyridinecarboxamidines was synthesized by the condensation of substituted anilines with cyanopyridines in the presence of aluminum chloride or sodium amide and these compounds were evaluated for antiinflammatory activity by the carrageenin-induced rat paw edema assay. In the synthesis of N^1-alkoxyphenyl pyridinecarboxamidines, it was found that o-alkoxyanilines reacted with aluminum chloride to afford o-aminophenol, while m- and p-alkoxyanilines were scarcely dealkylated. Sodium amide was successfully used for the condensation of o-alkoxyanilines with cyanopyridines. Among several active derivatives, N^1-(2,4-dichlorophenyl) pyridinecarboxamidine and N^1-(4-chlorophenyl)-pyridinecarboxamidine exhibited significant antiinflammatory activities.

• 社団法人日本薬学会の論文
• 1983-07-25

著者

• 松岡 俊和

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 市川 正孝

  福山大学薬学部

• 市川 正孝

  Faculty Of Pharmaceutical Sciences Kumamoto Univerisity

• 久野 拓造

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 久野 拓三

  熊本大学薬学部

• 田崎 正信

  熊本大学薬学部

• 津本 幸之助

  熊本大学薬学部

• 田崎 正信

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 津本 幸之助

  Faculty of Pharmaceutical Sciences, Kumamoto University

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