Coupling Reaction of 2-Hydroxyindoline with Arenes by BF_3・Et_2O. A Convenient Synthetic Method of Isolable Diastereomeric Atropisomers

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概要

• 論文の詳細を見る

• A simple method for synthesis of 2-aryl-substituted 3,3-dimethylindoline derivatives was established by the reaction of 1-acyl-2-hydroxy-3,3-dimethylindoline with electron-rich arenes in the presence of boron trifluoride-diethly ether in dioxane. In the reaction with β-naphthol, a pair of isolable diastereomeric atropisomers was isolated. The conformations of both atropisomers were determined by single crystal X-ray analyses. The substitution reaction behavior toward various arenes was accounted for in terms of frontier molecular orbital (FMO) theory.

• 公益社団法人日本薬学会の論文
• 1992-09-25

著者

• 原野 一誠

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 久野 拓造

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 原野 一誠

  熊本大学 薬

• 原野 一誠

  熊本大学薬学部

• 久野 拓三

  熊本大学薬学部

• 北村 武夫

  Daiichi College of Pharmaceutical Sciences

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