有機硫黄化合物の合成化学的研究(第9報)Willgerodt-Kindler反応条件下における4-ピコリンとmeta-置換アニリン類とからの選択的ペンゾチアゾール閉環体について
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In order to clarify in more detail the cyclization of thioanilide to benzothiazole under the modified Willgerodt-Kindler reaction conditions, 4-picoline was heated with metasubstituted anilines (I) in the presence of sulfur and the reaction also gave thioanilides and one of the two possible benzothiazoles. The latter was proved to have the structure of 5-substituted 2-(4-pyridyl) benzothiazoles (III) by independent synthesis. On the other hand, the expected two isomeric benzothiazoles (III and IV) were obtained from the oxidative cyclization of thioanilides by the modified Jacobson reaction.
- 公益社団法人日本薬学会の論文
- 1973-10-25
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