有機硫黄化合物の合成化学的研究(第5報) : Benzothiazole誘導体と有機過酸との反応

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概要

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• Comparative examinations were made on the behavior of 2-(2-pyridyl) benzothiazoles (Ia-c) to various organic peracids. In their reaction with peracetic acid, N-oxygenation of the pyridine ring produced 2-(1-oxido-2-pyridyl) benzothiazoles (IIa-c) and cleavage of the thiazole ring gave 2-(1-oxido-2-picolinamido) benzenesulfonic acids (IIIa-c) and 2-(2-picolinamido) benzenesulfonic acids (IVa-c). Oxidation with monopermaleic acid gave IIa-c as the main products, but N-oxygenation of the thiazole ring occurred to give a minute amount of 2-(2-pyridyl) benzothiazole 3-oxides (Va-c) and the dioxides, 2-(1-oxido-2-pyridyl) benzothiazole 3-oxides (VIa-c). In oxidation with pertrifluoroacetic acid, Va-c were the main products, with a small amount of IIa-c and VIa-c. Relative quantity of the products IIa, IIIa, and IVa was examined by varying the amount of peracetic acid to be added to Ia. Furgher, treatment of IIIa with peracetic acid was found to produce partial dehydroxylation.

• 社団法人日本薬学会の論文
• 1971-09-25

著者

• 古賀 弘

  熊本大学薬学部

• 久野 拓造

  熊本大学薬学部

• 古賀 弘

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 久野 拓三

  熊本大学薬学部

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