Studies on Organosulfur Compounds. XII. Syntheses and Pharmacological Activities of 2-Heterocyclic Substituted 4(3H)-Quinazolinones

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概要

• 論文の詳細を見る

• Four useful procedures for preparing a series of new 2-pyridyl-4(3H)-quinazolinones were investigated and twelve quinazolinones were evaluated for hypnotic activity. Some of them showed a definite hypnotic effect in intraperitoneal doses above 100 mg/kg, whose structure-activity relationship demonstrated that 3-pyridyl and 4-pyridyl substitution at 2-position of 4 (3H)-quinazolinone ring and ο-fluorophenyl and ο-chlorophenyl at 3-position are appropriate for the manifestation of hypnotic activity. A maximum hypnotic effect was observed in 2-(4-pyridyl)-3-(ο-fluorophenyl)-4(3H)-quinazolinone (1), the potency of which was equal to methaqualone in mice.

• 社団法人日本薬学会の論文
• 1975-09-25

著者

• 市川 正孝

  福山大学薬学部

• 市川 正孝

  Faculty Of Pharmaceutical Sciences Kumamoto Univerisity

• 辻 正義

  Hisamitsu Pharmaceutical Co. Inc.

• 久野 拓三

  熊本大学薬学部

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