抗黴剤の合成化学的研究(第14報) : 硫黄の存在下におけるアニリンと2-ピコリン-1-オキシドとの反応

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概要

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• 2-Picoline-1-oxide and 2-picoline were selected as the active methyl component, and reacted with aniline in the presence of sulfur at 160-165°. The relative yield of the thioanilide-type compound (A) and benzothiazole-type compound (B) thereby formed was examined relative to reaction time. There was a great difference in the behavior of the products A and B according to the difference in the active methyl component. When 2-picoline-1-oxide was used, formation of aniline hemisulfate (III) was observed during the reaction. It was also found that, in this reaction, deoxygenation of 2-picoline-1-oxide was produced by sulfur. Therefore, reaction of pyridine-1-oxide and 4-picoline-1-oxide with sulfur was examined and both were found to be deoxygenated at 140-150°.

• 社団法人日本薬学会の論文
• 1970-05-25

著者

• 古賀 弘

  熊本大学薬学部

• 久野 拓造

  熊本大学薬学部

• 久野 拓三

  熊本大学薬学部

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