Studies on Organosulfur Compounds. XIV. Sulfurations and Oxidations of 2,3-Disubstituted 4 (3H)-Quinazolinones

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概要

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• A series of 2-pyridyl-3-phenyl-4 (3H)-quinazolinone and the anthranilate was reacted with phosphorus pentasulfide to give the corresponding 4 (3H)-quinazolinethiones, which were oxidized with hydrogen peroxide to afford readily the above 4 (3H)-quinazolinones. The hydrogen peroxide oxidation of them in trifluoroacetic acid gave the 1,1'-dioxide and that in acetic acid gave the 1'-oxide. The nuclear magnetic resonance spectra of oxidation products were compared. It was found that some 4 (3H)-quinazolinethiones (Vc, VIa) were effective against several kinds of gram-positive bacteria, while exchange of the carbonyl group of 4 (3H)-quinazolinone by thione resulted in a loss of action for central nervous system.

• 社団法人日本薬学会の論文
• 1976-09-25

著者

• 城戸 裕

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 柴田 元雄

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 市川 正孝

  福山大学薬学部

• 城戸 裕

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 久野 拓三

  熊本大学薬学部

• 村岡 敬治

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 柴田 元雄

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 柴田 元雄

  熊本大学 薬

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