消毒剤の微生物分解(第5報)Chlorhexidineの一新脂溶性分解物, p-Chlorophenylurea

概要

論文の詳細を見る
To clarify the degradation pathway of chlorhexidine by a microbe, Pseudomonas sp. strain No. A-3,the identification of microbial chlorhexidine-degradation products was attempted. A new lipophilic chlorhexidine-degradation product was isolated by extraction with ethyl acetate from the culture medium of the strain, and purified by preparative thin-layer-chromatography by use of Silica gel. The chemical structure of this product was examined by infra-red, ^1H-NMR and fast atom bombardment mass spectra studies. By the spectroscopic data, this product was identified as p-chlorophenylurea and assumed to be a new degradation product of chlorhexidine by this strain.
社団法人日本薬学会の論文
1990-04-28