Microbial Degradation of Disinfectants. Structures of Chlorhexidine Degradation Intermediates, CHDI-B, CHDI-BR and CHDI-D, Produced by Pseudomonas Sp. Strain No. A-3

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Three chlorhexidine degradation intermediates, named CHDI-B, CHDI-BR and CHDI-D, were purified from the incubation mixture for chlorhexidine degradation by Pseudomonas sp. strain No. A-3. The structures of these compounds were determined by spectroscopic analyses of ^1H-NMR, ^<13> C-NMR and mass spectroscopy. CHDI-B has a structure in which 1 mol of 1-carboxyethyl is substituted at imine in the guanidyl group adjacent to the hexane moiety in chlorhexidine. CHDI-BR has a structure in which the carboxylic-OH in the 1-carboxyethyl moiety in CHDI-B condensed with imine in the adjacent guanidyl group to form a ring. CHDI-D has a structure in which 2 mol of 1-carboxyethyl are substituted at two imine in guanidyl groups adjacent to the hexane moiety in chlorhexidine.
社団法人日本薬学会の論文
1996-04-30