Reaction of Aromatic N-Oxides with Dipolarophiles. I. Reaction Products of 3-Picoline 1-Oxide with Phenyl Isocyanate

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概要

• 論文の詳細を見る

• The reaction of 3-picoline 1-oxide (VI) with phenyl isocyanate (I) in dimethylformamide at 110° gave the cycloadducts VII and VIII in 33.7 and 24.1% yield, respectively. The reaction at 150° gave 2-anilino-3-methylpyridine (IX) and 2-anilino-5-methylpyridine (X), along with a small amount of VII. Hydrolysis of VII and VIII in alcoholic potassium hydroxide affords IX and X, respectively. The structures of VII and VIII were discussed in the light of spectroscopic data. IX and X were identified by comparison with the authentic samples prepared by an alternative route.

• 公益社団法人日本薬学会の論文
• 1974-07-25

著者

• 久野 拓造

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 久野 拓三

  熊本大学薬学部

• 村岡 敬治

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 吉川 伸

  Daiichi College Of Pharmaceutical Sciences

• 吉川 伸

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 村岡 敬治

  Faculty Of Pharmaceutical Sciences Kumamoto University

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