Synthesis of Organosulfur Compounds. VIII. Cyclization Products from the Modified Willgerodt-Kindler Reaction
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概要
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In order to clarify in more detail the cyclization mechanism of thioanilide to benzothiazole under the modified Willgerodt-Kindler reaction conditions, 2-picoline (III) was heated with meta-substituted anilines (IV) in the presence of sulfur and the reaction also gave thioanilides and one of the two possible benzothiazoles. The latter was proved to have the structure of 5-substituted 2-(2-pyridyl)benzothiazoles (VI) by independent synthesis. On the other hand, the expected two isomeric benzothiazoles (VI and VII) were obtained from the oxidative cyclization of thioanilides by the modified Jacobson reaction.
- 公益社団法人日本薬学会の論文
- 1973-03-25
著者
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久野 拓造
Faculty Of Pharmaceutical Sciences Kumamoto University
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藪田 裕子
Faculty of Pharmaceutical Sciences, Kumamoto University
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