クマリン誘導体の合成研究(第17報) : 4-Hydroxy-3-sulfanilamidocoumarin誘導体の合成
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In order to obtain 4-hydroxy-3-sulfanilamidocoumarin derivatives, nitration of 4-hydroxycoumarins with nitric acid (sp. gr. 1.38) in glacial acetic acid solution was carried out. The nitro compounds thereby obtained were reduced to amino compounds, derived to N^4-acetylsulfanilamido compounds by the use of N-acetylsulfanilyl chloride, and hydrolyzed to 4-hydroxy-3-sulfanilamidocoumarin derivatives. Antibacterial tests of these derivatives on general bacteria and tubercle bacilli showed that their action against general bacteria was rather poor but 4-hydroxy-7-amino-3-sulfanilamidocoumarin (Vd) alone showed a strong action against tubercle bacilli. Acute toxicity (LD_<50>) of Vd was 2.1 g./kg. to by
- 公益社団法人日本薬学会の論文
- 1966-11-25
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