Intestinal Absorption Characteristics of Buformin and Phenformin in Rats

概要

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Absorption characteristics of buformin and phenformin, the hypoglycemic biguanides, were studied in the in situ rat small intestine. It was suggested that the small intestinal absorption of these biguanides is probably mediated by passive process. The absorption of these biguanides from the ileum was more rapid than that from the jejunum, and such the difference was not associated with the accumulation characteristic of the drugs in the intestinal tissues. From observations on the release of the components such as membrane phosphorus, lipid phosphorus, and protein from the jejunum and ileum, it was suggested that the more rapid absorption of these biguanides from the ileum would be attributable to that the release of membrane components from the ileum was much larger than from the jejunum, resulting in a much increased permeability of the ileum to the drugs.
公益社団法人日本薬学会の論文
1976-07-25