Studies on Steroidal Compounds. VII. Synthesis of 1α-Methyl Steroids.
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概要
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The Grignard reaction of 5α-cholest-1-en-3-one (IIIa) in the presence of cuprous chloride gave 1α-methyl-5α-cholestan-3-one (IVa). (IVa) was brominated and dehydrobrominated to give 1α-methylcholest-4-en-3-one (VIa). (VIa) was hydrogenated over palladium-charcoal to give 1α-methyl-5β-cholestan-3-one (VII). Discussions were made on configuration of C-1 methyl group. Similarly, 17β-hydroxy-5α-androst-1-en-3-one (IIIb) was transformed into (IVb) and (VIb).
- 公益社団法人日本薬学会の論文
- 1962-05-25
著者
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森 弘
Chemical Research Department Teikoku Hormone Mfg. Co. Ltd.
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森 弘
Research Laboratory, Teikoku Hormone Mfg. Co., Ltd., Shimosakunobe, Kawasaki
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