1,4-Addition of Vinylmagnesium Bromide to α, β-Unsaturated Steroidal Ketones. II. Reaction of 1-En-3-oxo Steroids
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概要
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The reaction of 1-en-3-oxo A/B trans steroid with vinylmagnesium bromide in the presence of cupric acetate afforded 1α-vinyl-3-oxo steroid. The configuration of the vinyl group introduced by the reaction was found to be α-oriented by the transformation of II into the lactone (VIII). The stereochemistry of the reduction of 1α-alkyl-3-oxo steroids and 5β-alkyl-3-oxo steroids with complex metal hydride was also studied.
- 社団法人日本薬学会の論文
- 1975-05-25
著者
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森 弘
Chemical Research Department Teikoku Hormone Mfg. Co. Ltd.
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大内 力男
Chemical Research Department, Teikoku Hormone Mfg. Co., Ltd.
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大内 力男
Chemical Research Department Teikoku Hormone Mfg. Co. Ltd.
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