Stem cell plasticity in hematopoietic system
スポンサーリンク
概要
- 論文の詳細を見る
Bone marrow (BM) contains hematopoietic stem cells (HSC) which differentiate into all mature blood cells and marrow stromal cells that provide the microenvironment for hematopoietic stem/progenitor cells along with the capability to differentiate into mature cells of multiple mesenchymal tissues including fat, bone and cartilage. Recent studies indicate that adult BM also contains cells which can differentiate into nonhematopoietic cells of ectodermal, mesodermal and endodermal tissues other than hematopoietic tissues, including liver, pancreas, kidney, lung, skin, GI tract, heart, skeletal muscles and neural tissues. Studies describing this multipotentiality of BM cells have become a focus of interest because clinical applications in the treatment of damaged or degenerative diseases would be at hand using easily obtainable cells. However, presently, definitive evidence explaining the mechanism of this multipotentiality of bone marrow stem cells is lacking. In this review, we summarize recent progresses and controversies in the multipotentiality of adult bone marrow-derived stem cells to non-hematopoietic tissues.
- 日本炎症・再生医学会の論文
- 2005-03-25
著者
-
NAKAHATA Tatsutoshi
Department of Pediatrics, Kyoto University
-
Heike Toshio
Department of Pediatrics, Graduate School of Medicine, Kyoto University
-
Heike Toshio
Department Of Pediatrics Graduate School Of Medicine Kyoto University
-
Heike Toshio
Department Of Cardiovascular Medicine Kyoto University
-
Nakahata Tatsutoshi
京都大学 医研究発達小児科学
-
Nakahata Tatsutoshi
Department Of Clinical Oncology The Institute Of Medical Science The University Of Tokyo
関連論文
- Clinicopathological characteristics of erythroblast-rich RAEB and AML M6a in children
- Acute Myeloid Leukemia with Multilineage Dysplasia in Children
- PE-263 Neural Cell Adehesion Molecule is Upregulated by Metabolic Stress and Enhances the Cardiomyocyte Survival(PE044,Molecular Biology (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- FRS-064 NF-kB-dependent Induction of MicroRNA-146 Downregulates ErbB4 and may be Involved in the Deterioration of Cardiomyocyte Survival(FRS13,Novel Molecular Mechanisms of Heart Failure 2 (M),Featured Research Session (English),The 73rd Annual Scientific
- PE-454 Cell Line-dependent Differentiation of Mouse Induced-pluripotent Stem Cells into Cardiomyocytes(PE076,Regeneration (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-272 Cyclin-dependent kinases-9 is required for the differentiation of mouse ES cells into cardiac myocytes.(Development and differentiation(02)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-233 MicroRNA-133 Regulates the Expression of GLUT4 by Targeting KLF15 and is Involved in Metabolic Control in Cardiac Myocytes(Metabolism/Biochemistry/Energetics(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circu
- OE-166 Upregulation of MicroRNA Targeting Retinoid X Receptor A Contributes to Development of Cardiac Hypertrophy(Molecular biology, myocardium (M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-760 Cyclin-Dependent Kinases-9, as a Novel Component of p300/GATA-4 Complex, is Involved in Differentiation of Mouse ES Cells into Cardiac Myocytes(Development and differentiation-2, The 71st Annual Scientific Meeting of the Japanese Circulation Societ
- PE-419 Enkephalin is Required for Adipocyte Differentiation and is Involved in Impaired Glucose Tolerance in Rat Model of Type II Diabetes(Diabetes/Obesity/Metabolic syndrome-06, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-417 Activation of TG-interacting Factor by Insulin Regulates Adipocyte Differentiation(Diabetes/Obesity/Metabolic syndrome-06, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-409 Functional Cloning of the Genes which Regulates GLUT4 Trafficking in Cardiac Myocytes(Diabetes/Obesity/Metabolic syndrome-05, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-172 miR-133 Controls GLUT4 Expression by Targeting KLF15 in Cardiomyocytes(Metabolism/Biochemistry/Energetics-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-171 Oxidative Stress Induces GLUT4 Translocation by Dual AMPK Kinase Activation in Cardiac Myocytes(Metabolism/Biochemistry/Energetics-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- A Specific Inhibitor of Histone Deacetylase, Trichostatin A, Promotes Differentiation of Embryonic Stem Cells into Cardiac Myocytes
- OE-317 MicroRNA-206 Controls Expression of α-and β-Myosin Heavy Chain Genes in Cardiac Myocytes(Molecular biology, myocardium-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-109 Trapping of Genes that Encode Secreted and Transmembrane Proteins in H9C2 cardiomyoblasts(Growth factor/Cytokine-1(H/M), The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-024 Up-Regulated Expression of MicroRNA-143 in the Adipose Tissue of High-Fat Diet-Induced Obese Mice(Diabetes/Obesity (basic), The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-349 Leptin Induces Physiological and Compensated Growth of the Left Ventricles Following Myocardial Infarction in Vivo(Diabetes/Obesity/Metabolic syndrome-7 (H) PE59,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanes
- PE-245 Adipocyte-derived Serotonin Regulates Adipocyte Differentiation via an Autocrine/paracrine Mechanism(Diabetes/Obesity/Metabolic syndrome-8 (H) PE41,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation
- PE-103 The Role of cAMP/PKA Pathway in the Differentiation of Embryonic Stem Cells into Cardiac Myocytes(Development and differentiation-2 (M) PE18,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society
- Notch ligand Delta-1 differentially modulates the effects of gp130 activation on interleukin-6 receptor α-positive and -negative human hematopoietic progenitors
- Hematopoietic Capability of CD34^+ Cord Blood Cells: A Comparison With CD34^+ Adult Bone Marrow Cells
- Glycoprotein 130 and c-kit Signals Synergistically Induce Thrombopietin Production by Hematopoietic Cells
- Current Status of Hematopoietic Cell Transplantation for Adult Patients with Hematologic Diseases and Solid Tumors in Japan
- Ring/marker chromosome derived from chromosome 7 in childhood acute megakaryoblastic leukemia with monosomy 7
- Repetitious Appearance and Disappearance of Different Kinds of Clonal Cytogenetic Abnormalities After Allogeneic Bone Marrow Transplantation
- Second Transplantation from HLA 2-Loci-Mismatched Mother for Graft Failure Due to Hemophagocytic Syndrome after Cord Blood Transplantation
- Delivery Route in Bone Marrow Cell Transplantation Should be Optimized According to the Etiology of Heart Disease
- OE-187 Granulocyte colony-stimulating factor protects cardiac myocytes from mitochondrial injury(Growth factor/Cytokine(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Subclinical central pontine myelinolysis following liver transplantation
- Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision
- Partial seizures in leukoencephalopathy with swelling and a discrepantly mild clinical course
- OE-196 Identification of Signaling Pathways that Mediate Myocardial GLUT4 Translocation using a Novel Lenti Viral-mediated GLUT4 Reporter Gene(Metabolism/Biochemistry/Energetics-1 (H) OE33,Oral Presentation (English),The 70th Anniversary Annual Scientific
- Non-progressive viral myelitis in X-linked agammaglobulinemia
- Regulation of human FcεRI β chain gene expression by Oct-1
- Characterization of leukemic cells in CD2/CD19 double positive acute lymphoblastic leukemia
- Differentiation of embryonic stem cells into cardiac myocytes
- Prognostic significance of the BAALC isoform pattern and CEBPA mutations in pediatric acute myeloid leukemia with normal karyotype : a study by the Japanese Childhood AML Cooperative Study Group
- Diabetes mellitus after stem cell transplantation in a patient with acute lymphoblastic leukemia : Possible association with tacrolimus
- Successful Allogeneic Bone Marrow Transplantation in a Patient with Acute Myelogenous Leukemia and Cytomegalovirus Retinitis
- Ex Vivo Expansion of Human Hematopoietic Stem Cells
- Ex Vivo Expansion of Human Hematopoietic Stem Cells
- IgE-activated mast cells in combination with pro-inflammatory factors induce T_h2-promoting dendritic cells
- Suplatast Tosilate Inhibits Human Mast Cell Development from Cord Blood Progenitors
- Prevalence of Mutations in the FGFR3 Gene in Individuals with Idiopathic Short Stature
- Stem Cell Plasticity in the Hematopoietic System
- Effects and serum levels of thrombopoietin in a case of chronic thrombocytopenia with achondroplasia
- Changing Prevalence and Severity of Childhood Allergic Diseases in Kyoto, Japan, from 1996 to 2006
- Synergistic action of interleukin-10 (IL-10) with IL-3, IL-4 and stem cell factor on colony formation from murine mast cells in culture
- Procedures for prevention of perinatal group B streptococcal diseases : a multicenter questionnaire survey of hospitals in the Kyoto Neonatal Disease Study Group, Japan
- Stem cell plasticity in hematopoietic system
- Current Knowledge on the Pathophysiology of Fanconi Anemia: From Genes to Phenotypes
- Cytokines Regulate Development of Human Mast Cells from Hematopoietic Progenitors
- Avoidance of Reintubation by Using Sedation during Noninvasive Positive Pressure Ventilation in a 3-Month-Old Infant with Postoperative Respiratory Failure
- Hematopoietic stem cell transplantation with reduced intensity conditioning from a family haploidentical donor in an infant with familial hemophagocytic lymphohistocytosis
- The Effect of Past Food Avoidance Due to Allergic Symptoms on the Growth of Children at School Age
- Patient with neonatal-onset chronic hepatitis presenting with mevalonate kinase deficiency with a novel MVK gene mutation
- Guidance on the use of canakinumab in patients with cryopyrin-associated periodic syndrome in Japan