Synthetic Osteopontin-derived Peptide SVVYGLR can Induce Neovascularization in Artificial Bone Marrow Scaffold Biomaterials
スポンサーリンク
概要
- 論文の詳細を見る
We have previously reported that an osteopontin-derived SVVYGLR peptide exhibited potent angiogenic activity in vitro and in vivo. In the present study, the focus points were on the in vitro effect of SVVYGLR on bone marrow stromal cell proliferation, as well as its in vivo effect on bone tissue formation when grafts made of CO_3Ap-collagen sponge - as a scaffold biomaterial containing the SVVYGLR motif - were implanted. SVVYGLR peptide promoted bone marrow stromal cell proliferation. When a CO_3Ap-collagen sponge containing SVVYGLR peptide was implanted as a graft into a tissue defect created in rat tibia, the migration of numerous vascular endothelial cells - as well as prominent angiogenesis - inside the graft could be detected after one week. These results thus suggested that our scaffold biomaterials including the peptide could be useful for bone tissue regeneration.
- 日本歯科理工学会の論文
著者
-
OKAZAKI Masayuki
Department of Biomaterials Science, Graduate School of Biomedical Science, Hiroshima University
-
YATANI Hirofumi
Department of Fixed Prosthodontics, Okayama University Graduate School of Medicine and Dentistry
-
HIRATA Isao
Department of Biomaterials Science, Graduate School of Biomedical Sciences, Hiroshima University
-
Matsumoto Takuya
Division Of Oromaxillofacial Regeneration Course For Integrated Oral Sciences And Stomatology Osaka
-
HAMADA Yoshinosuke
Department of Molecular Pathology, Osaka University Graduate School of Medicine and Health Science
-
EGUSA Hiroshi
Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry
-
KANEDA Yoshitoshi
Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry
-
KAWAGUCHI Naomasa
Department of Molecular Pathology, Osaka University Graduate School of Medicine and Health Science
-
HIRAO Takafumi
Department of Molecular Pathology, Osaka University Graduate School of Medicine and Health Science
-
YAO Makiko
Department of Molecular Pathology, Osaka University Graduate School of Medicine and Health Science
-
DAITO Kiyoshi
Department of Pediatric Dentistry, Osaka Dental University
-
SUZUKI Mayuka
Department of Molecular Pathology, Osaka University Graduate School of Medicine and Health Science
-
DAITO Michiharu
Department of Pediatric Dentistry, Osaka Dental University
-
MATSUURA Nariaki
Department of Molecular Pathology, Osaka University Graduate School of Medicine and Health Science
-
Yao Makiko
Department Of Molecular Pathology Osaka University Graduate School Of Medicine And Health Science
-
Daito Kiyoshi
大阪歯科大学 小児歯科学
-
Daito Kiyoshi
Department Of Pediatric Dentistry Osaka Dental University
-
Egusa Hiroshi
Department Of Fixed Prosthodontics Osaka University Graduate School Of Dentistry
-
Suzuki Mayuka
Department Of Molecular Pathology Osaka University Graduate School Of Medicine And Health Science
-
Hirao Takafumi
Department Of Molecular Pathology Osaka University Graduate School Of Medicine And Health Science
-
Daito M
Osaka Dental Univ. Osaka Jpn
-
Daito Michiharu
Department Of Pediatric Dentistry Osaka Dental University
-
Kawaguchi Naomasa
大阪大学 医学系研究科心臓血管外科
-
Yatani Hirofumi
Division Of Oral Maxillofacial Regeneration Graduate School Of Dentistry Osaka University
-
Yatani Hirofumi
Department Of Fixed Prosthodontics
-
Yatani Hirofumi
Department Of Oral And Maxillofacial Rehabilitation Okayama University Graduate School Of Medicine A
-
Okazaki Masayuki
Department Of Fixed Prosthodontics Osaka University Graduate School Of Dentistry
-
Okazaki Masayuki
Department Of Biomaterials Science Graduate School Of Biomedical Science Hiroshima University
-
Matsuura Nariaki
Department Of Molecular Pathology Course Of Allied Health Sciences Graduate School Of Medicine Osaka
-
Kawaguchi Naomasa
Department Of Molecular Pathology Osaka University Graduate School Of Medicine And Health Science
-
Kaneda Yoshitoshi
Department Of Fixed Prosthodontics Osaka University Graduate School Of Dentistry
-
Hamada Yoshinosuke
Department Of Molecular Pathology Osaka University Graduate School Of Medicine And Health Science:de
-
Hirata Isao
Hiroshima Univ. Hiroshima Jpn
-
Date Masataka
Department Of Pharmacology Osaka Dental University
-
Hirata Isao
Department Of Biomaterial Science Division Of Molecular Medical Science Hiroshima University Graduat
-
Okazaki Masayuki
Hiroshima Univ. Hiroshima Jpn
-
Okazaki Masayuki
Department Of Biomaterial Science Division Of Molecular Medical Science Hiroshima University Graduat
-
Matsuura Nariaki
Department Of Functional Diagnostic Science Osaka University Graduate School Of Medicine
-
Daito Miho
Department Of Pediatric Dentistry Osaka Dental University
-
Matsuura Nariaki
Department Of Cardiothoracic Surgery The University Of Tokyo
-
MATSUMOTO Takuya
Division of Cardiology, Sanda City Hospital
-
HAMADA Yoshinosuke
Department of Functional Diagnostic Science,
-
KAWAGUCHI Naomasa
Department of Cardiovascular Pathology, Osaka University Graduate School of Medicine and Health Science, Osaka, Japan
関連論文
- Effects of high-dose major components in oral disinfectants on the cell cycle and apoptosis in primary human gingival fibroblasts in vitro
- Creation of highly functional CO_3Ap-collagen scaffold biomaterials
- Apoptotic and Necrotic Influence of Dental Resin Polymerization Initiators in Human Gingival Fibroblast Cultures
- Regulatory Mechanism of Human Connective Tissue Growth Factor (CTGF/Hcs24) Gene Expression in a Human Chondrocytic Cell Line, HCS-2/8^1
- Chemical analyses of hydroxyapatite formation on SAM surfaces modified with COOH, NH_2, CH_3, and OH functions
- Analysis of Chemical Interaction of 4-MET with Hydroxyapatite Using XPS
- Spectroscopic Characterization of Enamel Surfaces Irradiated with Er:YAG Laser
- Effect of Presilanization Filler Decontamination on Aesthetics and Degradation Resistance of Resin Composites
- Chemical analyses of hydroxyapatite formation on SAM surfaces modified with COOH, NH_2, CH_3, and OH functions
- Carbon Ion Irradiation Suppresses Metastatic Potential of Human Non-small Cell Lung Cancer A549 Cells through the Phosphatidylinositol-3-Kinase/Akt Signaling Pathway
- Integrins α2β1, α5β1 and αvβ5 Are Related to Tumor Growth and Metastasis of Non-small Cell Lung Cancer
- Control of Pore Size in L-lactide/ε-caprolactone Copolymer Foams for Tissue Regeneration by the Freeze-drying Method
- Synthetic Osteopontin-derived Peptide SVVYGLR can Induce Neovascularization in Artificial Bone Marrow Scaffold Biomaterials
- Role of Acidic Amino Acid for Regulating Hydroxyapatite Crystal Growth
- Advantages of TOF-SIMS Analysis of Hydroxyapatite and Fluorapatite in Comparison with XRD, HR-TEM and FT-IR
- Osteopontin-derived Peptide SVVYGLR Induces Angiogenesis In Vivo
- Salivary Amylase Activity of Rats Fed a Low Calcium Diet
- New Type Scaffold Biomaterials with Magnesium Accelerating Osteoblast Adhesion and Bone Formation
- Morphological and Crystallographic Properties of Tooth Enameloid of Medaka (Oryzias latipes)
- Ultrasonic Tissue Characterization of the Atherosclerotic Carotid Artery : Histological Correlates of Carotid Integrated Backscatter
- Changes in oral microbial flora during antileukemic therapy
- Y-box binding protein expression in thyroid neoplasms : Its linkage with anaplastic transformation
- Possible Involvement of IGF-I and Neurotrophins in Fibroblast Proliferation
- 15-Deoxy-Δ12'14-prostaglandin J2 and Its Precursors Target Phosphoinositide 3-kinase and p38 MAPK to Accelerate Proliferation in the Human T Cell Leukemia Cell Line MOLT-4F
- Comparative Studies of the Effects of Adenosine and ATP on All-trans Retinoic Acid, 1, 25-dihydroxy-vitamin D_3 and Phorbol 12-myristate 13-acetate-induced Differentiation in U937 Human Leukemia Cells
- Alteration of the Expression of A 2 a Adenosine Receptor and Toll-like Receptor 4 in Macrophage Cell Lines
- Expression and Nuclear Localization of p65 in Brain and Retina of Streptozotocin-induced Diabetic Rats with Hyperglycemia
- Effect of a Low Calcium Diet on the Levels of Protein Kinases Activity in Rat Parotid Glands
- Effect of a low calcium diet on the salivary amylase in weaning rats
- Tumorigenesis facilitated by Pten deficiency in the skin : Evidence of p53-Pten complex formation on the initiation phase
- Possible Involvement of p38 in Mechanisms Underlying Acceleration of Proliferation by 15-Deoxy-*^-prostaglandin J_2 and the Precursors in Leukemia Cell Line THP-1
- TEM/EDX Observation of Micro-beads of Magnetically Activated Cell Sorting (MACS) System and Separation Trial of Mouse Mesenchymal Stem Cells from Bone Marrow Cells by MACS System
- Bone-like Layer Growth and Adhesion of Osteoblast-like Cells on Calcium-deficient Hydroxyapatite Synthesized at Different pH
- Oxaliplatin induces mitotic catastrophe and apoptosis in esophageal cancer cells
- Initial Evaluation of a Ceramic Form as a Reconstructive Material for Bone Defects
- Effect of Carboxyl Group in O-Methacryloyl-N-Acyl Tyrosines on Adhesiveness to Unteched Human Dentin
- Correlation of Dentin Bond Durability with Water Absorption of Bonding Layer
- Steric Effects of N-Acyl Group in O-Methacryloyl-N-Acyl Tyrosines on the Adhesiveness of Unetched Human Dentin
- Effects of fibronectin cleaved by neuropsin on cell adhesion and migration
- Degree of immobilization of synthetic RGDS(PO_3H_2)PA peptides on titanium surfaces
- Effects of Gene Transfection of Human bcl-2 on Concordant Cardiac Xenografts in Hamster to Rat Model
- CHORONIC ADMINISTRATION OF ANGIOTENSIN II RECEPTOR ANTAGNOST,TCV-116 PREVENTED CONGESTIVE HEART FAILURE IN THE CARDIOMYOPATHIC HAMSTER(UM-X7.1)
- A Small-molecule Approach to Bone Regenerative Medicine in Dentistry
- SEM Observation of Collagen Fibrils Secreted from the Body Surface of Osteoblasts on a CO_3apatite-collagen Sponge
- Clinical Observations on the Development of Third Molars
- Calcification of the Permanent Anterior Teeth Observed in Panoramic Radiographs
- Bone formation ability of carbonate apatite-collagen scaffolds with different carbonate contents
- Estrogenic Activity of Phthalate Esters by In Vitro VTG Assay Using Primary-cultured Xenopus Hepatocytes
- 3D Imaging of Intraductal Spread of Breast Cancer and Its Clinical Application for Navigation Surgery
- Change in Microstructure and Solubility Improvement of HAp Ceramics by Heat-Treatment in a Vacuum
- Design, Synthesis and Antiangiogenic Activity of the Vitamin D Binding Protein-Macrophage Activating Factor(DBP-maf)-Derived Synthetic Peptide
- Predictive factors for anthracycline-based chemotherapy for human breast cancer
- Osteoblast Proliferation Behavior and Bone Formation on and in CO_3apatite-Collagen Sponges with a Porous Hydroxyapatite Frame
- Zoledronic acid delays wound healing of the tooth extraction socket, inhibits oral epithelial cell migration, and promotes proliferation and adhesion to hydroxyapatite of oral bacteria, without causing osteonecrosis of the jaw, in mice
- Fracture Resistance of Inlay-retained Fixed Partial Dentures Reinforced with Fiberreinforced Composite
- In Vitro Study on Marginal and Internal Fit of CAD/CAM All-Ceramic Crowns
- Application of a Dental CAD/CAM System to the Production of All-ceramic Crowns
- Studies on Laser Applications to Dental Hard Tissues
- Development of Biomedical Materials Carrying Immobilized Functional Peptides and Discovery of an Angiogenic Peptide
- Porcelain Veneer Bonding to Dentin and the Curing Performance of Plasma-arc Light with Respect to Porcelain Thickness
- Porcelain Veneer Bonding to Enamel with Plasma-arc Light Resin Curing
- Detailed Consideration of Physicochemical Properties of CO_3apatites as Biomaterials in Relation to Carbonate Content Using ICP, X-ray Diffraction, FT-IR, SEM, and HR-TEM
- Distinct different intra-tumor distribution of FDG between early phase and late phase in mouse fibrosarcoma
- Analysis of Gene Expression during Differentiation Induction of Normal Human Periodontal Ligament Cells into an Osteoblast Lineage
- Utility of Salivary sIgA as a Marker for Assessing the Stress Caused by Dental Treatment
- Differentiation of dental pulp stem cells into a neural lineage
- Differentiation of Rat Dental Pulp-derived Cells into an Osteoblastic Lineage
- In vitro Osteogenic Differentiation Potential of Dental Pulp Stem Cells
- Simultaneous Determination of Alteration of a Variety of Macrophage Functions Related to Natural Immunity Following Treatment with a DP Receptor Agonist
- Obturation of dentinal tubules by a tannin-fluoride preparation (HY agent)
- Increase of acid resistance in dentin by a tannin-fluoride preparation (HY agent)
- Obturation of Dentinal Tubules with Tannin-Fluoride Preparation (HY Agent) Incorporated into Glass Ionomer Cement
- Expression of p57/Kip2 Protein in Pancreatic Adenocarcinoma
- Electrophoretic Deposition Behavior of Ceria-stabilized Zirconia/Alumina Powder
- Acceleration of bone formation with BMP2 in frame-reinforced carbonate apatite-collagen sponge scaffolds
- Radiographic Observations on Root Resorption in the Primary Dentition
- Immobilization of Simulated Reducing Agent at the Surface of SiO_2 Fillers in Dental Composite Resins
- A Preliminary Evaluation of Electromyographic Activities of Masseter Muscles during Speech in Myalgia Patients
- Cell Adhesion and Proliferation Patterns on Mixed Self-assembled Monolayers Carrying Various Ratios of Hydroxyl and Methyl Groups
- Higher Concentrations of Fluoride Ions Dramatically Inhibit the Survival of Osteoblasts
- Relations Among TMD, Bruxism, Lifestyle, and Psychological Stress
- Chewing Side Continuity and Masticatory Performance
- Analysis of Internal Defects in All-ceramic Crowns Using Micro-focus X-ray Computed Tomography
- Stress Analysis of Endodontically Treated Anterior Teeth Restored with Different Types of Post Material
- In Vitro Study on Marginal and Internal Fit of CAD/CAM All-ceramic Crowns
- Finite Element Analysis of Fiber-reinforced Fixed Partial Dentures
- Non-Working Contact Does Not Initiate Primary Occlusal Trauma
- Three dimensional measurements of the palate using a semiconductor laser : The influence of anterior cross bite on the palate in deciduous dentition
- DNA microarray analysis of dental pulp fibroblasts exfoliated from deciduous teeth
- TNF-α enhances MMP-2 production in deciduous dental pulp fibroblasts
- Three dimensional measurement of the palate using the semiconductor laser : On the influences of the palate of maxillary protrusion with finger sucking
- The role of anti immune response on adenosine stimulated macrophages
- An investigation of the special practitioner system of pediatric dentistry in Japan
- Utility of salivary biomarker for stress induced by dental treatment
- The preparation of PLLA/calcium phosphate hybrid composite and its evaluation of biocompatibility
- A possible role of phospholipase C and phospholipase D in chemotaxis
- Pulmonary tumor thrombotic microangiopathy showing aggressive course after transurethral resection of urinary bladder : an autopsy case report
- Stem cells in dentistry – Part I: Stem cell sources
- Stem cells in dentistry – Part II: Clinical applications
- Effects of Moxibustion on Body Core Temperature Responses in Rats